Israeli researchers from the Technion are developing a solution that addresses the shortages in seasonal harvesters: robots that pick fruit for us.

Throughout history, early summer has often signaled the time to harvest. Harvesting, of course, has evolved considerably. As opposed to ancient times when mobilizing the whole community was necessary to fully harvest grain, there are sophisticated machines nowadays run by just a few individual operators that quickly navigate through fields and efficiently process many acres at a time.

However, in the case of fruits, there is still a need for a great deal of manual labor throughout the harvesting process today, but workers are in short supply. The farming labor and resource shortage is reported in many countries across the world including the United States, Australia, the United Kingdom, Vietnam and Brazil. Unharvested produce leads to a loss of food quality and spurs enormous economic losses, a fact that will become more evident and problematic as the world population continues to increase. 

In a new Israeli study, researchers from the Technion developed a ground mobile robot that could drastically advance fruit agriculture and harvesting. The robot, whose development was led by Associate Professor Amir Degani from the Technion’s Environmental, Water, and Agriculture Engineering Department, will have the capability to use one or multiple small-sized drones to perform the operations required in orchards much more accurately and cheaper than the methods used by farmers today.

The study was recently presented at the “Water and Environmental Engineering in the Face of Climate Change” conference of the Environmental, Water, and Agriculture Engineering Department at the Technion’s Faculty of Civil and Environmental Engineering. 

The Need for Better Fruit-Picking Robotics

The gap between the number of seasonal laborers and the volume of work is expected to significantly expand as the world population continues to grow. By 2050 there are expected to be more than 9 billion people in the world, and in order to feed them all it will be necessary to increase the volume of food production anywhere from 35-60 percent (unless the whole world switches to a plant-based diet). 

One might expect though that with such a highly populated world there would be no shortage of working personnel, but sadly this is not the case.

“People have been moving from villages to cities for decades – and fewer people want to engage in manual labor,” Degani explains. “It’s seen in construction and agriculture, and it happens everywhere – including in countries with very large populations, like India and China. In India, for example, harvesting coconut is a very important task – but fewer and fewer people want to work in that field.”

According to him, the problem also exists in Israel. “As in many Western countries, there are quite a few years in Israel where apples fall to the ground because no one is there to pick them in time.”

Degani believes the solution to these problems lies in robots that know how to pick fruits. 

“Just as automation has solved many of the problems that plagued field crops, like using machines such as combine harvesters, once we adapt this strategy to plantations farmers will be able to better streamline and reduce the uncertainty that currently surrounds the acquisition of skilled seasonal labor for specific times of the year,” he says.

It is important to note that automating harvests should be approached differently than those used for field crops, which involve rough, large, and overly expensive machines. 

“In field crops, massive harvesting is carried out all over the area––usually indiscriminately,” says Degani. “Picking edible fruit should be gentle and selective. The fruits should be picked one by one and handled carefully.”

Interestingly, he claims that the robotic arms currently used in factories, which have a large range of motion and accurate precision capabilities that humans can only dream of, are not suitable for the task. 

“Although these robotic arms know how to perform a pre-planned operation, their sensing and decision making capabilities are limited and are not suitable for agriculture,” he says. “Agriculture is a more difficult world. Agriculture takes place in an uncertain environment with fluctuating changes in light and outdoor conditions, so the robot must have complex sensing and decision making capabilities.” According to him, the robot should not be too expensive of an alternative because otherwise many farmers will not be able to afford it.

Call in Air Support

Degani and his team began to approach the challenge of the harvesting robot’s development by first addressing its maneuverability in the orchard, a task more complicated than it sounds.

“In order for the robot to patrol and weave through all the trees and detect pests or ripe apples, for example, it must know where it exactly is,” Degani explains. The orchard environment is relatively homogeneous from a ground point of view, with most of the trees looking about the same and the GPS reception not being particularly reliable.

This obstacle gave rise to the idea of establishing a connection between a ground mobile robot and a drone. The researchers found that when utilizing the perspective of a low-flying drone, the top-view observation of the orchard provides a unique signature of every tree formed by the shape of its canopy. The first study on the subject was published in the robotics and automation section of the IEEE magazine. 

Currently, researchers are working on additional ways in which the farming robot can use small drones to perform the operations required for harvesting orchards. First, they demonstrated that a drone could hover around a tree, creating a detailed three-dimensional image of each of the trees in the area. These are needed to make the harvesting process more efficient and reflect more modern model of precision agriculture.

“The meaning of ‘precision agriculture’ is that instead of making decisions on issues relating to things like fertilization, irrigation, thinning, pest management, or harvesting at the entire field level, we will look at the agricultural plot at a higher resolution and make such decisions down to the individual tree level,” explains Degani.

This will make it possible to increase the volume of produce, by providing the best conditions for each individual tree, and beyond that, save the use of resources such as water, fertilizer, and potentially dangerous pesticides.

Degani believes the solution lies in the capabilities of a ground mobile robot that knows how to navigate around the wood, perform precise mechanical operations, and even pollinate flowers––another separate project currently under development in the laboratory.

A Shift From Human to Robot?

Today, Degani’s studies are in the prototype stage, and they demonstrate possibilities for future development. In any case, there are already several automation attempts in the fruit harvesting industry represented by Israeli companies such as FFRobotics, a robot equipped with the ability to emulate human hand-picking, and Tevel Aerobotics Technologies, which developed a flying harvester that is scheduled to enter its pilot phase in the coming year.

Beyond that, not only is the identity of the harvester expected to shift from human to robot – but the structure of the orchard itself is also speculated to change.

“The way we engineer and grow trees will change, and they will be designed in a way that is right for robotic harvesting,” Degani explains. “Even today you can see in the world apple orchards that look almost like a two-dimensional wall on which fruit grows. This is not genetic engineering but mechanical engineering operations designed to make the orchard grow as efficiently as possible.” The new orchard structure allows for denser planting and is designed to enable easier harvesting for both humans and robots alike. Studies are currently underway to determine the most efficient configuration, in preparation for an era in which robots will enter the agricultural landscape.

In the end, according to Degani, everything is aimed at becoming more efficient simply because we have no other choice. 

“Even in modern agriculture, the farmer will be very important, but he will need much fewer working hands,” he says. “Like quite a few things, the data will be at the center, to help him make informed decisions, and the robots will carry out the tasks in the field. This is what will direct the efficiency so that we can reach a sufficient crop target that will feed all humans,” he says.

“Because there will be less land, less resources, and less manpower over time, there is a need to find a solution. Otherwise, fruits like apples will be accessible only to the very rich,” Degani concludes.

Funding will be used to support more than a dozen studies

A new university grant program in Israel with a budget of over $1 million will support researchers in their quest for new food technologies.

The ministries of Agriculture and Innovation, Science and Technology initiated the program with an emphasis on alternative proteins.

The ministries launched a call for proposals last Thursday, in collaboration with the Good Food Institute (GFI) Israel, a non-profit organization that seeks to promote research and innovation in food technology.

The food technology sector is a broad field that includes nutrition, packaging, food safety, processing systems, new ingredients and alternative proteins. These include plant-based meat, dairy and egg substitutes, dairy products, cultured meat and seafood, insect proteins, and fermentation products and processes.

Many of the technologies used in this field are based on academic research. 

The technologies of two major Israeli cultured meat companies, Aleph Farms and Future Meat, are based on bioengineering research developed by their respective co-founders, Professor Shulamit Levenberg of the Technion – the Israel Institute of Technology – and Professor Yaakov Nahmias of the Hebrew University of Jerusalem. 

Both are leading academics in the field of tissue engineering.

Ministry funding will support a dozen university studies offering science and technology solutions in the areas of cultured meat, fermentation processes and plant-based substitutes. 

These studies can be aimed at improving the final product or the production process itself, the ministries said.

The study is related to a problem in AI and robotics called autonomous decision-making under uncertainty.

Researchers at the Technion – Israel Institute of Technology found a way to simplify decision-making and problem-solving under uncertainty in a way that reduces the amount of information computers need to analyze.

A new peer-reviewed study published in the International Journal of Robotics Research, led by Prof. Vadim Indelman, who heads the Autonomous Navigation and Perception Lab (ANPL) at Technion’s Faculty of Aerospace Engineering, and Khen Elimelech, shows the feasibility of reducing the amount of time for computers to process information without compromising the success of completing a function.

“We demonstrate that we can significantly reduce computation time, without harming the successful execution of the task,” the researchers said. “We also demonstrate that computation efforts can be reduced even further if we accept a certain loss in performance loss that our approach can evaluate online. In an age of self-driving cars and other robots, this is an approach likely to enable autonomous online decision making in challenging scenarios, reduce response times, and achieve considerable savings in the cost of hardware and other resources.”

The study is related to a problem in AI and robotics called autonomous decision-making under uncertainty, which concerns the capability of AIs to complete tasks reliably and autonomously over time in an unpredictable environment.

Technion noted that autonomous agents often do not have access to the variables related to a particular problem and instead function based on a “belief” based on probability models and measurements.

Illustrative image of AI. (credit: PIXABAY)

Belief space planning

A major area of research in the new study was computationally efficient decision-making under these conditions, called belief space planning. In order to solve this problem, an AI must weigh the costs and benefits of a potential action, which requires the researchers to predict how the “belief” will change over time.

The findings may help researchers solve decision-making problems using simplification and show that there are ways to save considerable amounts of computation time without a loss of accuracy.

Forsight Raised $10 million in seed funding in March 2021.

Israeli medtech startup ForSight Robotics is developing a surgical robotic platform to deliver what it describes as high precision and cost-effective vision-saving surgery. Forsight just raised $55 million in a Series A round of funding led by The Adani Group alongside existing investors Eclipse Ventures and Mithril Capital.

Founded in 2020 CEO Daniel Glozman, Ph.D., Joseph Nathan, M.D. and Moshe Shoham, Ph.D, Forsight declares that its mission is to transform the practice of ophthalmic surgery through a next generation robotic platform combining “state of the art robotic microsurgical technology, advanced visualization technologies, and next generation cognitive computing methods.”

Joseph Nathan previously directed healthcare commercialization at the Technion Israel Institute of Technology, where he forged partnerships worth over $1 billion with global pharmaceutical and med-tech companies. Daniel Glozman has specialized in robotics for medical applications for over 20 years, heading R&D at Medtronic Ventor Technologies, Magenta Medical, Diagnostic Robotics, and Guide-X — which he also founded.

Israeli medical professionals have been behind many new procedures to save people’s vision over the years. Losing your vision is one of the most frightening things which can happen to people. Israeli startup OrCam produces new technology for the blind and other people with visual deficiencies. Its MyEye is wearable technology that can give eyesight to the blind. But it does not heal them.

Forsight Robotics, however, tries to heal blindness. The company explains that many of the leading causes of blindness worldwide can be prevented through timely surgical procedures. Ophthalmic microsurgery is complex and challenging, requiring many years to master, and there is a shortage of trained ophthalmic surgeons to meet the demand worldwide. Creation of a robotic surgical platform will allow one to deliver consistent excellent results while scaling up ophthalmic surgery to solve the problem of preventable blindness worldwide.

“These are exciting times that will enable the transformation of ophthalmic surgery from art to science,” Forsight’s Dr. Joseph Nathan once declared.

“We are thrilled to bring robotics into the world of ophthalmic surgery,” Dr. Glozman once said. “Our goal is to democratize this highly sophisticated procedure, enabling patients around the world to easily access the treatment that can restore their vision.”

Technion-patented technology enables monitoring and early identification of changes in the condition of respiratory patients at home or in hospital.

The Jerusalem Post has partnered with ExitValley, a digital platform that enables anyone to invest in Israel’s start-up ecosystem and share in its success. In this article, we are pleased to introduce NanoVation-GS, an Israeli company that has developed a first-of-its-kind nanosensor-based technology for monitoring and managing chronic respiratory conditions at home or hospitals while reducing hospitalizations. 

The patented technology was discovered at the Technion and is undergoing clinical trials in Israel and the EU. “The technology enables surveillance and early identification of changes in the patient’s condition. In addition to reducing hospitalizations, it is also expected to reduce their duration”, says the company’s CEO and co-founder, Dr. Gregory Shuster, Ph.D.

NanoVation-GS has developed a unique technology for monitoring patients with chronic lung diseases, with an emphasis on obstructive diseases such as COPD – Chronic Obstructive Pulmonary Disease, which enables early detection of worsening of symptoms and helps reduce prolonged and frequent hospitalizations by allowing the patient to receive appropriate early treatment. “The device is designed to measure important respiratory parameters without any discomfort or effort needed by the patient,” says Dr. Shuster.

NanoVation company’s CEO and co-founder, Dr. Gregory Shuster, Ph.D. (Credit: NanoVation)

The development is based on advanced nanosensor technology, which for the first time allows accurate monitoring of changes in respiratory function without any discomfort or effort from the patient, and is particularly sensitive to fluctuations and changes in several critical respiratory parameters. “One of the things we identified was the gap in technologies related to respiratory monitoring. When you look at monitoring in cardiology, for example, there are much broader tools than in respiratory monitoring,” Dr. Shuster explains.

The solution provides the ability to manage chronic respiratory diseases via the cloud, allowing doctors to review data from any location, during hospitalization, and during the follow-up period at home, which also enables the creation of “big data”-bases of all relevant information. “The system is simple to use at home without any need for professional assistance or in a clinical environment. It operates in a non-invasive method, measures normal and effortless breathing, and uses exclusive biomarkers which were identified by the company’s technology,” Dr. Shuster adds.

“The system is simple to use at home without any need for professional assistance or in a clinical environment”.

Dr. Gregory Shuster

NanoVation-GS was founded at the Technion by a leading experienced team, including Dr. Shuster- founder and CEO and senior researcher in nanomaterials and materials engineering, and Prof. Hossam Haick, founder and CSO, a leading researcher and expert in nanotechnology. The company has an exclusive license for its first patent from the Technion and two additional patents owned by the company, which are in the registration phase.

NanoVation-GS has been granted a prestigious development grant by the European Innovation Council (EIC), which only supports start-ups identified as companies with a significant impact and groundbreaking technology. In addition, the company has previously received grants from the Israel Innovation Authority. “Breathing monitoring technologies today can be divided into two groups,” says Dr. Shuster. “One is the technologies that measure normal breathing, which are not invasive or annoying to the patient, but the data collected is limited to the parameter of breathing rate only.

Nanovation Technology (Credit: NanoVation)

“The second group provides a series of respiratory parameters, but it requires the patient to perform certain breathing maneuvers. This is a complicated test for the patient to perform at home. It is bothersome, unpleasant for the patient, and the doctor who receives the data cannot know whether the test was performed properly, because he did not see the patient do it.

“What we do is combine the benefits of these two worlds,” says Dr. Shuster. “On the one hand, our measurement takes a few minutes, during which the patient puts on the sensor and does nothing extra. On the other hand, the data we extract provides a series of respiratory parameters, which are very relevant to changes in the disease condition. All this in one simple test, which can also be done routinely at home. The patient cannot get an incorrect measurement, because all he has to do is breathe naturally.”

The company’s SenseGuard product has been tested so far in successful clinical trials at leading partners in Israel and around the world, including Halle-Saale University Hospital in Germany, Nicosia Lung Center in Cyprus, and in Israel at Ichilov Medical Center, Poriah Hospital, Nazareth Hospital, Rambam and Barzilai Hospitals and the Galilee Medical Center.

NanoVation-GS has completed all procedures needed for obtaining the necessary regulatory approvals for medical devices, including CE certification and international ISO standards. The company will work to update its existing CE certification to the new standard (MDR), while also planning to obtain FDA approval at a later date. NanoVation-GS is ready to start marketing activities in Europe towards entry into the COPD monitoring market, which is its first phase destination market, and later will turn to other territories and examine further commercial and clinical applications.

“Right now, we are focusing on the medical field, looking at chronic respiratory patients, but plans for the future are varied,” Dr. Shuster concludes. “The use of our technology can also be extended to other respiratory and non-respiratory diseases, sleep monitoring and even entering the field of wellness, by measuring and helping to manage the level of stress, assisting with breathing exercises in yoga and more.”

Attendees get to experience virtual flights using an in-flight simulator of the personal electric plane, which should go on the market in 2024.

In October 2021, ISRAEL21c reported that an Israeli flying car startup had started taking pre-orders for its personal electric plane (an eVTOL, short for “vertical takeoff and landing,” vehicle).

Now AIR, the company behind this latest and greatest way to commute to work, has unveiled the first full-scale prototype of its inaugural vehicle. The company took the wraps off its high-flying product at the Kentucky Derby.

Attendees were able to sit inside the aircraft and experience “virtual flight” using a simulator. The craft didn’t actually take off and fly, though.

Also at the Derby launch, AIR announced a new partnership with Aeroauto to establish a UAM (an “urban air mobility” vehicle) showroom and dealership in Florida.

A simulation of the AIR ONE in flight. Photo courtesy of AIR

“People have been dreaming of these incredible machines for decades,” notes Sean Borman, CEO of Aeroauto. “It is a great honor to [bring] an international manufacturer to North America as an AIR Brand Ambassador, while becoming their North American Flagship retailer for sales, service, and customer training center.”

Despite the excitement, the company still has plenty of work left to do. AIR is currently preparing to begin “hover testing” and is working with the FAA to formalize its application to operate flying cars in the US. Customer deliveries are still expected by 2024 – a couple of years wait but years ahead of the competition.

So far, AIR has completed a successful drop test and has finalized the first stage of the power and communication system integration on the craft. The company’s flagship eVTOL, the AIR ONE, has a number of unique features, including foldable wings and retracting landing gear that allow it to fit inside an average suburban garage.

Rani Plaut, CEO of AIR. Photo courtesy of AIR

The AIR ONE is an electric battery-powered, fixed-wing, two-person craft propelled by eight vertical lift rotors. It has a range of 110 miles on a single charge at speeds up to 150 mph. It can carry a maximum payload of 440 pounds and charges up in less than an hour. The floor of this innovative eVTOL is partially made of glass – great for passing the time on the way to work.

AIR CEO Rani Plaut told ISRAEL21c last year that the company’s goal is “to make something as easy as a car with a practical range and a practical price. If we can do that, I think we can make a real difference.”

Other Israeli startups working on flying cars include Urban Aeronautics, Eviation, Pentaxi and Flytrex.

More information about the AIR ONE here.

Netafim analysis shows corn grown with drip irrigation releases 53% fewer carbon emissions compared to flood-irrigated corn.

Corn is the third largest plant-based food source in the world and the most important crop in the United States, where 1.2 billion metric tons of corn were produced last year.

Corn is also cultivated in China, South America, India, Ukraine and across Europe, as food for both humans and livestock, as a biofuel and as a crude material for industrial purposes.

Now, results of a Life Cycle Analysis study show that the environmental impact of all those cornfields is significantly reduced by the use of drip irrigation as opposed to flood or sprinkler irrigation.

The study was conducted by EcoChain during 2020 for Israel’s Netafim, the global leader in sustainable precision irrigation solutions.

Highlights of the study:

  • Corn grown with drip irrigation releases 53 percent fewer carbon emissions compared to flood-irrigated corn and 39% fewer carbon emissions compared to sprinkler irrigation.
  • Drip-irrigated corn requires 24% less fertilizer than when it is grown with flood irrigation, and nearly 17% less fertilizer than when it is grown with sprinkler irrigation.
  • Drip-irrigated corn produces 45% more per kilograms per hectare when compared to flood, and 23% more when compared to sprinklers.

An earlier study showed that rice grown using Netafim’s drip irrigation technology out-produces conventional paddy rice farming, uses 70% less water, and diminishes methane emissions to almost zero.

“We’ve been showing the world how to grow more with less for nearly 60 years and our pioneering technology is now critical to mitigate the impacts of climate change,” said Netafim Global Chief Sustainability Officer John Farner.

“Today, farmers are not only challenged by record-high energy and fertilizer costs, but also increased pressure to reduce their overall environmental footprint, all while producing our global food supply,” said Farner.

“Adoption of precision irrigation for corn, along with other crops around the world, is critical to stabilize farmer livelihoods, reduce the carbon footprint of farming, and ensure a food-secure future.”

With 33 subsidiaries and 17 manufacturing plants worldwide, Netafim offers customized irrigation and fertigation solutions to millions of farmers, from smallholders to large-scale agricultural producers, in over 110 countries.

Electreon demonstrates a prototype stretch of road to Italian ministers, company executives; luxury car firm Maserati expresses interest in installing tech too

Israeli company Electreon, whose technology is integrated into roads that recharge the batteries of electric vehicles as they travel on them, is on track to design a lane for shuttles and service vehicles at Bergamo Airport northwest of Milan, Italy, the company said in a statement.

The project was clinched Friday at an event that officially launched a one-kilometer (0.62 miles) recharging circuit that Electreon has been testing in Brescia, northern Italy, since November 2020.

The launch was attended by Italian ministers along with senior executives from vehicle, infrastructure, and tech companies.

Bergamo Airport staff members are to test their vehicles out on the prototype road, called Arena of the Future, and if all goes to plan, the airport will move toward a commercial agreement with Electreon to create an electric lane on the airport’s tarmac.

According to an Electreon press release, the luxury car company Maserati also said it wanted to try its e-vehicles out at the Arena, with a view to acquiring the technology at its plants.

The prototype road was built following the October 2020 signing of a memorandum of understanding between Electreon and the Italian toll road infrastructure company Societa’ di Progetto Brebemi SpA. The goal of the MOU is to integrate Electreon’s wireless electric road system into infrastructure projects in Italy.

Cutting the ribbon to officially open the Arena of the Future, a demonstration electric charging road created in Brescia, northern Italy, by Israeli start-up Electreon. (Electreon)

At Friday’s event, Francesco Bettoni, head of the holding company that administers the A35 toll road, known as BreBeMi, set out the company’s vision for integrating Electreon’s technology into a stretch of road from Bergamo to Turin.

Solar fields are to be built along the road to power the system renewably.

“Europe has clearly stated its goals for the transition to sustainable transportation. We are ready for the commercial phase of the Arena of the Future technology,” Bettoni said.

He added, “I’m pleased to say that there’s great interest in the technology and we’re getting inquiries from many local authorities who are interested in integrating the technology into intercity roads.”

Aimed at reducing air pollution, the electric road does away with the need for recharging stations. According to Electreon’s website, a system of copper coils is laid beneath the asphalt to transfer energy from the electricity grid to the road and to manage communication with approaching vehicles. Receivers are installed on the floor of the vehicles to transmit the energy directly to the engine and the battery while the vehicles are on the go. Communication with all management units and all registered vehicles is via cloud technology.

The system allows for smaller batteries on electric buses, releasing more room for passengers, utilizes existing roads, and saves time because vehicles do not have to stop to charge or refuel.

An electric bus and an electric Fiat 500 try out the circuit at Arena of the Future, a demonstration electric charging road created in Brescia, northern Italy, by Israeli start-up Electreon. (Electreon)

During Friday’s event, an electric Fiat 500 car driving at 84 kilometers (52 miles) per hour around the track started with a battery that was charged 22 percent and finished with a charge of 48%.

An IVECO bus driving at up to 60 kilometers (37 miles) per hour also finished with an increased charge.

Electreon has numerous projects across Europe and in the US.

In Israel, it is partnering with the city of Tel Aviv-Jaffa and the Dan Bus Company in a large-scale commercial deployment of its wireless charging infrastructure to power electric buses.

Last year, Electreon was one of four Israeli firms named to TIME magazine’s annual list of “100 Best Inventions.”

Israeli medical device company SoniVie, announced on Sunday that it received Investigational Device Exemption (IDE) approval from the US Food and Drug Administration for its REDUCED1 (Renal Denervation using Ultrasonic Catheter EmitteD energy) pilot study to treat resistant hypertension patients with renal artery denervation using its proprietary therapeutic intra-vascular ultra-sound system, or TIVUS. 

Renal denervation with TIVUS is a minimally invasive procedure that uses high-frequency non-focused ultra-sound energy to burn away nerves in the renal artery. The TIVUS catheter is inserted into the pulmonary artery and selectively damages nerves afflicted by the disease without touching vessel walls or damaging adjacent tissues. This causes a reduction in the nerve activity, which decreases blood pressure and is meant for patients who suffer from resistant hypertension.

Resistant hypertension is defined as blood pressure that remains higher than 140/90 mmHg despite the use of three hierarchical classes of antihypertensive medications at their most appropriate tolerated doses. The condition affects millions of people around the world, increasing the risk of heart attack, stroke, and kidney failure. 

Founded in 2014, SoniVie has developed a first-of-its-kind ultra-sound denervation platform with active programs establishing nuanced therapeutic solutions for pulmonary hypertension denervation, renal artery denervation for resistant hypertension, and lung denervation for obstructive pulmonary disease with chronic bronchitis.

“We are very pleased that the FDA has approved the REDUCED1 study,” said Christian Spaulding, chief marketing officer of SoniVie. “Sites initiation has started, and many clinical teams have responded very favorably about participating in the study.

“There is a significant number of patients that may benefit from our technology and we are genuinely happy for this important step towards the introduction of TIVUS in the US,” he added. “There is a lack of effective therapeutic solutions for patients suffering from resistant hypertension, and physicians are looking forward to a safe, effective and easy to use device treatment.” 

“This is a significant US regulatory milestone for SoniVie, starting the feasibility study using the ultra-sound ablation platform in the US for the renal denervation indication,” said Tomaso Zambelli, CEO of SoniVie. “This is a major step and priority in the company’s history.” 

On this World Blood Donor Day, let’s explore some Israeli tech that is making a difference to one of our most vital components: our blood

Hematological awareness is important as body vitality is exclusively dependent on blood flow. Blood is our natural producer of oxygen and carbon dioxide, and it is also a key mechanism for medical identification. For decades, doctors have prioritized blood analytics and testing as these results present in-depth information regarding diagnostics, treatment methods, and one’s overall physical state. Blood is as much the cure as it is the cause– blood donations are organized worldwide to act as a remedy for the shortage of blood and blood products that can single-handedly save hundreds of lives. Here in Israel, MedTech’s innovative efforts have always been advanced, yet amidst the effects of COVID-19 and how it continues to modify all spheres of society, Israeli MedTech innovations are at an all-time high. With the focus strictly on blood analytics, Israel’s start-up environment has pushed forth incentives and actions that have seemingly revolutionized how blood can be analyzed, detected, and measured. Here are some Israeli startups that play a role in hematology solutions.

PixCell

Blood diagnostic information, in most cases, does not do enough to create an effective impact on immediate health solutions and products. The devices and technologies that have been used thus far do not provide doctors and patients with substantial information when it matters most. Moreover, real-time blood testing is not accessible to everyone which presents numerous implications when patients are in emergencies. These obstacles have disrupted medical efforts for decades as there is a pressing need for in-depth, easily accessible blood diagnostic tools. In an accidental discovery made by a team of researchers at the Technion (Israel Institute of Technology), Viscoelastic Focusing (VEF) has been recognized as the saving grace toward efficient cell analytics. The Israeli startup PixCell has created the HemoScreen that uses advanced technology making use of VEF potential. This product uses a disposable cartridge with specific reagents to elicit a Complete Blood Count test. HemoScreen does not require maintenance or calibration and is versatile to fit the precise needs of its user.

PixCell was founded in 2008 with a keen focus on simplifying and regularizing real-time blood testing worldwide. Their research and entrepreneurial staff have surpassed company expectations with the discovery of Viscoelastic Focusing (VEF), paving a way for pivotal advancements in hematological efforts. Their team consists of Avishay Bransky (CEO, Co-Founder), Prof. Max Herzberg (Co-Founder), Armin Schon (CCO), Hanan Ben-Asher (COO, BD Manager), Mark Erez (CFO), Yaara Ben-Yosef (Director of RA and Clinical Affairs), and Eitan Hod (Director of QA and RA). PixCell has raised over $7 million in grant funding from the European Commission, the International Health-Tech Pilot Program, and the Israel Innovation Authority. In 2021 PixCell was acquired by Soulbrain Holdings.

RedC Biotech

The global supply of red blood cells has seeped far under worldwide medical demands. This shortage has served as a detriment to medical interventions such as trauma, childbirth, operations, chronic illness, cancer, and the list goes on. Red blood cells are the oxygen-carrying capacity of the body which is why 120 million blood units are donated each year, yet there is still a concerning decrease in these donations. Blood drives and donation sites, although they function as a temporary solution, are still not enough to compensate for the urgency in transfusion methods, productions, and resources. The Israeli startup RedC Biotech has initiated a “one blood type fits all” method with RedC Universal Red Blood Cell Transfusions. This product is suitable for almost every patient and provides a uniform potency. It is pathogen-free and donor free and also eliminates undesirable blood components as well as additional hospital testing.

Credit: RedC Biotech

RedC was founded in Haifa in 2015 by Dr. Ari Gargir. Over the past couple of years, the company has received $1.4 million in pre-seed and seed funding from PipelBiz. Their revolutionary technology addresses issues associated with industrial red blood cell production, and cost reductions. From the lab to global production, Red C Biotech is eager to scale the count of red blood cells to save lives worldwide. RedC has a small employee base but is growing in accordance with its production timeline.

Improdia

Current diagnostic tests cannot distinguish between acute and chronic inflammation, as well as monitoring immune functions that are pivotal for personalized treatment methods. With Improdia’s array of Unique BioMarkers, the innovative diagnostic company has developed a simple way to supervise inflammation levels for patients suffering from autoimmune and cancer diseases. ImproDdia’s technology department has made substantial discoveries enabling pharma companies a kickstart in their drug development processes as well as suggesting personalized treatment methods. Improdia’s Diagnostic Kit includes three easy-to-use, unique biomarkers with three distinct functions: the IMPC (for chronic inflammation), IMPI (for immunotherapy), and IMPD (for diabetes complications. IMPC evaluates the immune status and inflammatory pain levels of those with niche medical implications. It aids physicians in selecting the type and timing of specific treatments as well as monitoring the efficacy of such treatments. IMPI is a prognostic test for the efficiency of immunotherapy. It monitors the immune status of cancer patients before immunotherapy or chemotherapy. IMPD is a prognostic test for diabetes complications as it predicts the occurrence of these complications before they are medically obvious.

Improdia’s team consists of Miriam Lerner (Founder, Co-CEO, CTO), Gil Pogozelich (Chairman), Dr. Roy Eldor (Medical Director), Prof. Michal Baniyash (Inventor), and Prof. Ido Wolf (Member of the Scientific Advisory Board). The company has been based in Herzliya since 2012 and continues to aid doctors and patients in the diagnostic and management endeavours of those with chronic immune-mediated diseases.

Sight Diagnostics

Sight’s technology represents breakthrough innovations in diagnostic methodology. Their latest blood analyzer, Sight OLO, performs a Complete Blood Count, the most ordered blood test, in minutes. It’s compact and designed to be used in a variety of settings. OLO creates a digital version of a blood sample by capturing more than 1,000 highly detailed images from just two drops of blood obtained from a finger prick or venous sample. These images are then interpreted by proprietary and fully automated AI algorithms, and the results are available within minutes.

Sight OLO provides 5-part differential complete blood count (CBC) results with 19 parameters and sophisticated flagging capabilities, for on-site testing. It is the first CBC analyzer that is FDA 510(k) cleared for blood taken directly from either a finger prick or a venous sample. Sight OLO has been validated for use in patients 3 months and above, in a variety of CLIA-certified (Clinical Laboratory Improvement Amendments) moderately complex clinical settings such as hospitals, emergency departments, oncology clinics, pediatric practices, and urgent care locations. The sample preparation process can be completed in under one minute, with the full results ready in minutes on a touchscreen interface, printout, email, or via LIS (Latent Semantic Indexing)/middleware. Sight OLO comes factory calibrated for a quick setup with internal Failsafe systems and requires no maintenance. Its minimal training and step-by-step on-screen guidance are designed to be used by operators with any level of experience. OLO also has an Operator Management feature that allows for complete control over who can access the device, including traceability of operator activities.

Sight OLO was founded in 2011 by Yossi Pollack (CEO) and Daniel Levner (Chairman of the Scientific Advisory Board). The company is based in Tel Aviv, London, and Brooklyn with 300 employees. With investments from Koch Disruptive Technologies, OurCrowd, and Longliv, Sight Diagnostics has raised over $120 million to date. Sight has gained worldwide traction with partners eager to use and expand the company’s advanced technology. Among them are Boston Children’s Hospital, Oxford University Hospitals NHS Foundation Trust, and Nicklaus Children’s Hospital in Miami.

EFA

Handheld blood test diagnostic tools are not affordable for the average patient and consumer. Most of these tools require laboratory conditions and specific preparations which fail to account for real-time informed decisions an individual may have to make. Israeli startup EFA developed RevDx™, a revolutionary, European Commission-approved, mobile, and fully automated diagnostic system to be used for different care, including primary care physicians, home care, emergency care, and remote care. RevDx™ is easy-to-use; from a finger prick, you get results within minutes. The application provides a Complete Blood Count test, the most requested hematology test worldwide which provides indications for broad clinical conditions such as infections, disease, fever, immune system, and anemia.

Founded in 2016 by Yoel Ezra (CEO), an engineer and a physicist who served in a technological-operation unit in the IDF for over 23 years, EFA is acting to develop the RevDx solution as a platform that will enable the creation of more diagnostic applications over time. Among the company’s investors are Maccabi Healthcare Services, eHealth Ventures, Merchavia, and Medison. The company currently employs 12 people.

OrSense

Diverse clinical settings have not found easy nor accurate methods to measure blood parameters as current testing devices and tools are not appropriately equipped for such conditions. The key to medical testing is to establish a comfortable environment for any and all patients; with invasive monitoring, though, this element is rather ignored. Israeli startup OrSense works to transform patient health through non-invasive monitoring as they develop and commercialize innovative monitoring technologies focused primarily on donor and patient comfort. Using their revolutionary SpectOLight ™ Occlusion Spectroscopy Technology, OrSense has developed the NBM 200 Device that detects blood hemoglobin (Hb), oxygen saturation levels and pulse rate (PR) values. Patients place their fingers on a ring-sensor probe where the portable desktop attached to the monitor device calculates and displays the figured measurements. To make matters even easier and more efficient, OrSense has developed a software application attached to the device that allows for Tablet or Smartphone use.

Since 1996 OrSense has been working worldwide to overcome key obstacles that do not account for comfortable, accessible, and efficient blood parameter testing. For over 20 years, OrSense has made substantial adjustments toward non-invasive monitoring technologies: the intellectual property portfolio at OrSense consists of 51 granted patents and over 20 additional applications. So far, OrSense has raised over $44.4 million in seed and grant funding from Israel HealthCare Ventures, Star Ventures, Saints Capital, The Lewis Trust Group, and Shimon Eckhouse. Their team consists of Yoav Resiman (Founder and CEO), Aharon Weinstein (VP of Research). Asher Zysman (CFO), and Chip Neff (President). OrSense is located both in Tel Aviv, and Raleigh, North Carolina, USA.

PatenSee

Patients who suffer from renal failure are required to be connected to a hemodialysis machine for a few hours, 2-3 times a week, via a fistula on the patient’s arm. The fistula is the point of connection between the hemodialysis machine and the patient for the treatment. One of the most dreaded complications for hemodialysis patients is fistula loss due to stenosis (blood clogging of the fistula) resulting in an inability to perform routine dialysis – a major risk to patient life. PatenSee is a medical device company (currently in the clinical stage) that has developed a contactless, machine vision-based, surveillance system for the early detection of vascular stenosis and/or a clogged fistula. The technology is designed to provide a very simple way to improve the quality of patient care and to support the nursing staff in the hemodialysis center without adding any burden on the patient or the clinic. The system can also be adapted to home use adding a critical diagnostic feature to home dialysis.

PatenSee was founded in 2019 as a portfolio company of MEDX Xelerator, a MedTech incubator working under a license from the Israel Innovation Authority. Hagay Drori and Oz Seadia founded PatenSee based on an unmet need presented to the MEDX Xelerator by a major strategic player in the dialysis field. Dr. Gal Goshen, PatenSee’s CEO, led it from its early concept through its first-in-human 60-patient clinical study, conducted less than two years after the company’s founding. PatenSee is currently raising a Series A round and is preparing for a multi-center, international, clinical trial of its second-generation imaging system.