The increased demand for sustainable energy sources prompted research groups to focus on battery research in order to store large-scale grid energy in a manageable and reliable manner. In addition, the rising demand of the electric vehicle industry, which mainly relies on current Li-ion battery technology, is expected to strain the current lithium production and divert it from more widespread use as portable consumer electronics. Currently, no technology has proven to be competitive enough to displace Li-ion Batteries.
Now, a team of researchers from the Technion – Israel Institute of Technology has developed a proof-of-concept for a novel rechargeable silicon (Si) battery, as well as its design and architecture that enables Si to be reversibly discharged and charged.
The research was led by Professor Yair Ein-Eli of the Faculty of Materials Science and Engineering. The team proved via systematic experimental works of the graduate student Alon Epstein and theoretical studies of Dr. Igor Baskin that silicon is dissolved during the battery discharge process, and elemental silicon is deposited upon charging. Several discharge-charge cycles were achieved, utilizing heavy doped n-type Si wafer anodes and specially designed hybrid-based ionic liquid electrolytes, tailored with halides (Bromine and Iodine), functioning as conversion cathodes.
This breakthrough could pave the way towards the enrichment of the battery technologies available in the energy storage market, with the technology potentially easing stress on the ever-growing market and serving the increasing demand for rechargeable batteries.
Silicon, as the second most abundant element on earth’s crust, was left relatively unexplored despite a high energy density of 8.4 kWh kg-1 on par with metallic Li 11.2 kWh kg-1. Silicon possesses stable surface passivation and low conductivity (dependent on the doping levels). Until now, no established rechargeable cell chemistry comprising elemental Si as an active anode has been reported outside LIB alloying anode.
In the past decade, several publications reported the incorporation of active silicon anodes in primary, non-rechargeable air-battery designs. Thus despite its high abundance and ease of production, the possibility of using Si as an active multivalent rechargeable anode was never explored until the team’s recent breakthrough.
A team of researchers from the Technion–Israel Institute of Technology has developed a proof-of-concept for a novel rechargeable silicon (Si) battery, as well as its design and architecture that enables Si to be reversibly discharged and charged.
Led by Professor Yair Ein-Eli of the Faculty of Materials Science and Engineering, the team proved via systematic experimental works of the graduate student, Alon Epstein and theoretical studies of Dr. Igor Baskin, that Si is dissolved during the battery discharge process, and upon charging, elemental Si is deposited. Several discharge-charge cycles were achieved, utilizing heavy doped n-type Si wafer anodes and specially designed hybrid based ionic liquid electrolytes, tailored with halides (Bromine and Iodine), functioning as conversion cathodes.
This breakthrough could pave the way towards an enrichment of the battery technologies available on the energy storage “super-market” technology, providing an ease on the ever-growing market and demand for rechargeable batteries.
Developments leading to this breakthrough
The increased demand for sustainable energy sources prompted the scientific community to focus on battery research capable of storing large scale grid energy in a manageable and reliable manner. Moreover, the rising demand of the EV industry, which mainly relies on current Li-ion batteries (LIBs) technology is expected to strain current Li production and divert it from more widespread use as portable consumer electronics. Currently, no technology has proven to be competitive enough to displace LIBs. Metals and elements capable of delivering multi-electrons during their oxidation process have been the focus of the research community for a long time due to their associated high specific energy densities.
Magnesium, calcium, aluminum and zinc received much attention as potential anode materials with varied levels of progress; yet none has managed to revolutionize the energy storage industry beyond LIBs, as all of these systems suffer from poor kinetic performance to lack of cell stability, and therefore, much is left to be explored. Silicon (Si), as the second most abundant element on earth’s crust (after oxygen) was left relatively unexplored despite a high energy density of 8.4 kWh kg-1 on par with metallic Li 11.2 kWh kg-1; Si possesses a stable surface passivation, low conductivity (dependent on the doping levels) and until now no established rechargeable cell chemistry comprising elemental Si as an active anode has been reported, outside LIB alloying anode.
In the past decade several publications (initiated originally in 2009 by Prof. Ein-Eli) reported the incorporation of active Si anodes in primary, non-rechargeable air-battery designs. Thus, despite its high abundance and ease of production, the possibility of using Si as an active multivalent rechargeable anode was never explored, until the team’s recent breakthrough.
The Formula Student competition in Europe this summer is a platform for new technological developments.
The Technion-Israel Institute of Technology Formula racecar team unveiled the first-ever autonomous electric vehicle in the team’s history since 2012.
They designed and built it for the Formula Student International Design Competition in Europe next month.
The Technion team placed first at the Formula Student competition in the Czech Republic in 2019, and first place in the first Formula Student Race held in Israel last year. This team also holds the title for the lightest car in the history of the European competition (132 kg).
Team leader Muans Omari, a master’s student in the Faculty of Mechanical Engineering, explained that the car world is shifting to electric and autonomous vehicles, and the Formula Student competitions have embraced this trend.
Nevertheless, the transition from an internal combustion engine to an electric propulsion system “took a lot of work and learning,” Omari added.
The Formula Technion team’s autonomous electric vehicle (A-EV) is no longer red and black as in past years, but blue, white and gray to symbolize electric propulsion.
The Formula Student competition is a platform for new technological developments. Each team’s performance is rated on a combination of engineering challenges plus driving skills demonstrated on the track.
The goal of the project is to enable students to acquire practical knowledge in planning as well as manufacturing vehicles.
“We are considered a good team,” Omari said. “We’re not as good as the German teams that are being supported by the largest car manufacturers and their engineers, but we already proved ourselves.”
Technion, Israel’s Institute of Technology is the oldest university in the country and one of the leading universities in the world.
Its Faculty of Biotechnology and Food Engineering is a unique department where expertise from many disciplines comes together.
Israel is a global centre of food and agri-tech, producing remarkable innovations, and attracting astonishing levels of investment.
But, like anywhere else in the world, there are problems; food waste, overfishing, unsustainable practices, feeding a growing population. Israel is facing all of the above and the issues are taxing its brightest minds.
The Food Matters Live Podcast has looked at innovation in Israel before, but in this episode we are going to get a unique insight into one of the world’s leading research centres.
The Faculty of Biotechnology and Food Engineering is led by Professor Marcelle Machluf, a remarkable woman who was named Lady Globe Magazine’s ‘Woman of the Year’ in 2018.
Her work has been included in the Israel Ministry of Science and Technology’s list of ‘Israel’s 60 Most Impactful Developments’.
During this episode of the Food Matters Live Podcast, we learn about the new Carasso FoodTech Innovation Center being built at Technion.
It has an R&D centre, packaging laboratory, kitchens, tasting, and evaluation units.
Professor Machluf says: “It’s not enough to just sit in the classroom. Our students need the right equipment to develop their ideas and they need to be prepared for whatever the future holds.”
Listen to the full episode to hear her views on the importance of building relationships to drive innovation, learn more about the work being done at Technion, and how the institute is going about developing a centre for ideas that haven’t yet been born.
Professor Marcelle Machluf, Dean of the Faculty of Biotechnology and Food Engineering, Technion
Professor Marcelle Machluf is renowned for her cutting-edge cancer and drug delivery research, and her work in tissue regeneration.
She is head of the Technion’s graduate Interdisciplinary Program in Biotechnology, a member of the Affiliate Engineering Faculty of the Technion Integrated Cancer Center, and former deputy executive vice president for research for the Technion’s Pre-Clinical Research Authority. She also works closely with the Russell Berrie Nanotechnology Institute.
Professor Machluf is developing a targeted drug delivery system using modified stem cells called Nano-Ghosts to home in on tumours, unleashing its therapeutic load at the cancer site.
She is also developing scaffolding for tissue engineering of the pancreas, heart, and blood vessels, and developing carriers for cell delivery with applications for treating diabetes and more.
She has a laboratory at Nanyang Technological University of Singapore, where she is working on a leading tissue regenerative project.
Professor Machluf has authored book chapters and more than 80 peer-reviewed journal papers in leading journals. Her work has been cited more than 2,800 times. She has six national patents and two approved international patents in the fields of drug delivery and tissue engineering.
She is the recipient of many honours including the Alon Award for excellence in science, the Gutwirth Award for achievements in gene therapy, the Hershel Rich Technion Innovation Award, and the Juludan Research Prize for outstanding research.
The pharmaceutical industry is considered one of the important sectors growth investors should focus on because of continuous research and development of new medicines, as well as commercialisation.
The development of new vaccines and medications for COVID-19 attracted a lot of investor attention in 2020, which caused biotech stock prices to skyrocket. This trend continued until 2021, resulting in rising biotech stock prices. However, the boom gave way to a biotech bear market in late 2021. This year, the broad market has performed poorly, but biotech shares have performed even worse, underperforming the broader markets.
Investors have become less interested in risky companies in the biotech sector because of high inflation and expectations for higher interest rates. The SPDR S&P Biotech ETF (XBI), an equal-weighted index of biotech stocks, has fallen 40% since January 1, 2021, and is down 23% so far this year. On the other hand, the S&P 500 is down 13.4% YTD. However, since mid-June, biotech stocks have begun a fast-paced recovery.
While current macro trends may hurt biotech stocks in the short term, innovative technology that is well managed has the potential to do very well in the long run. Covid emphasized this extensively, which has heightened market interest in coronavirus treatment and vaccine options. Given how oversold biotech stocks have become, many of these stocks are now appearing to be bargains.
Most biotech firms research and develop multiple drugs concurrently, providing these companies with multiple revenue streams and safe investment opportunities for investors. The current challenges seen by the biotech sector could create a fantastic buying opportunity for investors looking for a stock with the potential for significant long-term growth.
Given all of the above, here are 4 promising biotech companies to consider.
Intellia Therapeutics Inc (NTLA)
Intellia Therapeutics, founded in 2014, is a leading genome editing company that develops curative gene-editing treatments. The company’s programs include the treatment of transthyretin amyloidosis, hereditary angioedema, and acute myeloid leukemia; and proprietary programs focused on developing engineered cell therapies to treat various oncological and autoimmune disorders. Intellia also has licensing and collaboration agreements with various research institutes.
The company continues to make excellent progress with its clinical trials and is expected to present early-stage interim data from a couple of trials and make a major regulatory filing by the end of 2023. In recent financial results, Intellia reported positive progress in both the cardiomyopathy and polyneuropathy arms of the landmark Phase 1 study of NTLA-2001. The stock is down 45% YTD presenting a good time to add this stock to a growth investor’s portfolio as the positive events expected in the coming quarters might drive its stock higher in the coming months.
BioMarin Pharmaceutical Inc (BMRN)
BioMarin Pharmaceutical, Inc., founded in 1997, is a biotechnology company that engages in the development and commercialization of therapies for people with serious and life-threatening rare diseases and medical conditions. Its commercial products include Vimizim, Naglazyme, Kuvan, Palynziq, Brineura, Voxzogo, and Aldurazyme. The company’s pipeline includes Valoctocogene Roxaparvovec (Roctavian) which is in Phase III clinical trial for the treatment of Hemophilia A; BMN 307, an AAV5 mediated gene therapy which is in Phase 1/2 clinical trial; and BMN 255 which is in Phase 1/2 clinical tria for treating primary hyperoxaluria.
The company recently announced its Q2 earnings which surpassed analyst estimates. BioMarin reported $533.8 million in sales, up 6% Y/Y. Further, Voxzogo for achondroplasia (dwarfism) reported sales of $34.4 million. An estimated 446 children were being treated with commercial Voxzogo globally, compared to 284 children in Q1 FY22.
The stock is up 4% YTD and is expected to perform well in the long-term with the company’s commercial sales for Voxzogo in Japan and Australia expected to begin in Q3. BioMarin also expects that Roctavian will be approved in Europe in Q3, with FDA resubmission planned for September.
NurExone Biologic Ltd. (NRX.V)
NurExone is working on a treatment for traumatic central nervous system damage based on groundbreaking biological extracellular vesicles (E.V.) technology. This startup is developing ExoTherapies, in which exosomes are loaded with healing molecules, and an easy-to-administer delivery system to change the way traumatic spinal cord injury (SCI) is treated around the world. According to the World Health Organization, the estimated global SCI incidence is 40 to 80 new cases per million population per year.
NurExone’s first ExoTherapy, ExoPTEN, has shown very promising results for spinal cord injuries during animal studies. It promoted exon-growth functional recovery, or nerve regeneration. This suggests that NurExone’s groundbreaking and proprietary exosome-based therapy has the potential to provide a much-needed, functional-recovery providing treatment for SCI.
The company holds a worldwide exclusive license agreement with the Technion, Israel Institute of Technology in Haifa, for the development of technology, clinical trials, and commercialization. Nurexone (NRX.V) is now listed on the TSX Venture Exchange, following the completion of a Reverse Takeover Transaction.
Israel is home to more than 400 active biotech startups that have shown remarkable growth by leveraging advanced technologies. The country is known for investing the highest percentage of its GDP in R&D encouraging academic centers and research groups to develop breakthrough treatments. Given the availability of resources and support, alongside the fast-growing industry NurExone is pursing, the company is primed to experience significant growth in the coming years.
Vertex Pharmaceuticals Incorporated (VRTX)
Vertex, founded in 1989, focuses on the discovery, development manufacturing, and commercializing of breakthrough small molecule drugs for serious diseases including cystic fibrosis, infectious diseases, autoimmune diseases, and neurological disorders. The company reported strong second-quarter results with product revenues up 22% Y/Y to $2.20 billion.
The stock is up 24% YTD. Given the company’s recent pipeline development, the stock has more upside potential. Vertex’s CF (cystic fibrosis) drug TRIKAFTA recorded strong performance in the United States. As a result, the company expects the demand for CF drugs to remain high additionally driven by the launch of KAFTRIO outside the United States. Vertex has completed the Phase 3 study of TRIKAFTA/KAFTRIO in children 2 to 5 years old and expects to submit global regulatory filings for TRIKAFTA/KAFTRIO in children 2 to 5 years old this year.
Vertex has also filed a Supplemental New Drug Application (sNDA) with the U.S. Food and Drug Administration (FDA) and a Marketing Authorization Application (MAA) with the European Medicines Agency (EMA) for the use of ORKAMBI in children 12 months to less than 24 months old.
Conclusion
Biotech stocks have started to recover with some big players reporting positive growth in the recent quarter. Investors who add the right biotech companies to their portfolio now will be able to reap lucrative rewards in the long run when the bear market eventually subsides.
Researchers at the Israel Institute of Science and Technology are making great strides in how the disease is both detected and treated
Technion professors and graduates are continuing to make significant contributions in the field of cancer research.
Professor Yuval Shaked, along with startup, OncoHost, has created a blood test that will allow doctors to provide personalised treatment plans to cancer patients, Ibex Medical Analytics, headed up by Dr Daphna Laifenfeld (who researched it during her time at the university), has created an Artificial Intelligence-based cancer diagnostic software, while NanoGhost, co-founded by Professor Marcelle Machluf, is another technology “that targets cancer cells with modified adult stem cells loaded with medicine.”
Having already raised $5 million, NanoGhost – which innovatively delivers cancer medicine directly to tumour cells, allowing the potency to be reduced by a factor of a million – has been treating pancreatic, lung, breast, prostate and brain cancer successfully in mice.
Professor Machluf says: “This integration turns the NanoGhost platform from a ‘taxi’ that delivers the drug to the target into a ‘tank’ that participates in the war.
“The integrated platform delivers the drug to the tumour and enables a significant reduction in drug dosage yet still does the job. We also showed that our method does not harm healthy cells.”
NanoGhost is on track to begin clinical trials in 2023.
The university team has tested its research on mice in a novel trial
A team of scientists from Technion – Israel Institute of Technology has used genetically engineered muscle tissue to cure mice of type 2 diabetes.
Muscle cells are among the main targets of insulin, which is supposed to absorb sugar from the blood. However, in type 2 diabetics, this ability is reduced.
Up until now, restoring the metabolic activity of muscles has just been an unexplored idea. Now, however, the theory has been proven – thanks to Professor Shulamit Levenberg, Dean of the Faculty of Biomedical Engineering at the Technion and doctoral student Rita Beckerman.
Isolating the muscle cells and engineering them to be metabolically functional before transporting them back into the abdomen of the diabetic mice led to the now-healthy cells absorbing sugar correctly and improved blood sugar levels – both in the abdominal muscles and elsewhere in the body.
The mice remained cured of diabetes for the entire four-month period which they were observed.
Professor Levenberg said: “These cells worked hard and absorbed glucose, and also secreted factors that systematically affected the metabolism of the mice.
“The approach can be used to rescue mice from their diabetic situation, and now we hope to be able to use it in the future as a treatment for humans.”
“It’s such a novel approach that we really didn’t know what to expect, but we were extremely happy with the result”, Beckerman added.
“This could potentially, in the future, give human patients with Type 2 diabetes the possibility of having an implant and then going for a few months without taking any medications.”
The research is published in the peer-reviewed Science Advances journal.
Diabetes currently affects 4.7 million people in the UK, according to Diabetes UK – 90% of which will have type 2. Type 2 diabetes can lead to long-term complications such as heart disease, stroke, kidney failure and blindness.
This Israeli startup finds key ingredients in nature that are also found in breast milk
The ingredients that make mother’s milk the best possible thing for a baby will now be available for grownups.
Israeli food tech startup Maolac uses an algorithm that matches the key proteins in breast milk with alternative sources found in mushrooms, algae, and plants.
Everything that baby benefits from — protection against illness, anti-inflammatory qualities, and nutrition — will be utilized in a superfood for adults, Maya Ashkenazi Otmazgin, and biomedical engineer and the CEO for Maolac, tells NoCamels.
“We created an algorithm that can actually look at all the proteins inside breast milk and mix and match the key proteins responsible for different functionalities and then find them in alternative sources in nature, like mushrooms, algae, and plants,” she says.
Maolac is also said to be the first company in the world to identify and extract functional proteins from bovine colostrum, a nutrient-rich milky fluid that comes from the udder of cows in the first four to five days after giving birth, which is 95 percent equivalent to those found in breast milk, according to the firm.
Bovine colostrum produced by baby calves should not go to waste. Image by Erdenebayar Bayansan from Pixabay
Extra milk from calves– as much as 20 liters per cow — is thrown away after getting a certain amount from each one. “If we look for it, we will see 5 billion liters of bovine colostrum that the dairy industry does not use,” Ashkenazi Otmazgin says.
“The idea of transforming the first, nutrient-rich milk of cows that have just given birth into a source for human protein is a stroke of pure genius. Billions of liters of bovine colostrum are discarded each year. Maolac takes this waste and creates a product of huge potential benefit to millions at a time when the world is desperately searching for new sustainable sources of protein. The company is a perfect example of the circular economy in action,” said Jon Medved, CEO of OurCrowd, which has invested in the company.
Nursing vision
Otmagazin had the idea to create a superfood using nutritional ingredients found in breast milk while experiencing “the magic” of nursing her first child. She realized she wanted to harness the benefits of that breast milk for adults.
“I told myself – this is the ultimate superfood for mammals,” she says in a conversation with NoCamels during a short break between a hectic day of meetings. “There are different functionalities that breast milk can provide for a small human being and I realized we could leverage all the goodness to create something new inspired by a formulation that created the human species and actually brought us to where we are,” she says.
In 2018, Ashkenazi Otmazgin joined forces with Eli Lerner and immunity expert Dr. Ariel Orbach to form a food tech startup. The company just raised a $3.2 million seed funding round led by active crowdfunding platform OurCrowd with participation from The Kitchen FoodTech Hub founded by the Strauss Group, The Food Tech Lab, VentureIsrael, NEOME, and Mediterranean Towers Ventures.
Studies have shown that there are numerous benefits to breastfeeding a baby that both protect against illness and positively impact health and child development. According to the Cleveland Clinic in Cleveland, Ohio, USA, breast milk provides abundant and easily absorbed nutritional components, antioxidants, enzymes, immune properties, and live antibodies from the mother that attack germs and protect the baby from illness.
Maolac superfood products. Courtesy.
Maolac’s technology relies on a bio-convergence platform for the discovery of proteins based on machine learning and natural language processing search algorithms. The company identified more than 1,5000 known bio-active proteins in human breast milk and over 400 homolog proteins in bovine colostrum, and have since created thousands of human functional milk protein mixtures using similar ingredients found in plants and mushrooms, and other sources found in nature.
Ashkenazi Otmazgin stresses that the alternative sources must come from nature. “We don’t make them in a lab or genetically modify our mixtures.”
Maolac’s active ingredients work like breast milk to directly target specific body function, traveling through the bloodstream or gut to produce higher overall efficacy at lower dosages, a statement from Maolac said.
One of the ingredients has anti-inflammatory properties and is part of the first Maolac product line for humans. It will target athletes to reduce muscle strain and improve recovery time. The product will also target the elderly to support living and improved mobility. It will form the basis for the next generation of gut health solutions for humans and pets to help prevent severe cases of gut inflammation.
The second ingredient will be a part of products creating the next generation of probiotics, according to Otmazgin. It will contribute to a better digestive system to reduce inconvenience due to stress in the gut, irritable bowel syndrome (IBS), or other conditions
Maolac will use the seed funding they just raised to build a state-of-the-art facility that will feature small-scale production capabilities. The facility will also be able to create analytics and samples for customers and clinical trials.
The Maolac team. Maya Otmazgin is in the center. Courtesy.
Ashkenazi Otmazgin tells NoCamels that the startup is in advanced discussions on joint development agreements with several leading Israeli companies in the food and supplements markets. It is also in talks with several of the world’s leading dairy protein producers and global dairy, ingredient, and supplement companies.
“We have several contracts on the table with potential global manufacturers that will produce for us. Our intention is to go global,” says Ashkenazi Otmazgin, citing both the US and Europe.
“We want to be the next generation of smart ingredient companies that create precision proteins for the food supplements and cosmetics industries with a portfolio of products with different functionalities,” says Ashkenazi Ashkenazi Otmazgin, “We want to bring active ingredients in small doses that won’t have an influence on taste, texture, or colors of existing food products, so people will love to consume those products.”
Ashkenazi Otmazgin also admits that in the future, the company will go to other markets, like the baby formula market. “Not full formula, but functional ingredients for the industry,” she adds.
For now, though, the focus is breast milk.
“There are so many companies that work in the alternative space and don’t look at breast milk — there is something quite repulsive when you talk about it. But adults can take real advantage of it,” she says.
Two-minute AI profile saves physician from time-consuming trawl of medical records
The average doctor’s appointment lasts about 20 minutes — 30 if you’re lucky. The physician sees dozens of patients, many with complex histories and taking a range of medications. Every detail is important, but there’s no way a doctor can keep track of it all.
Enter Navina (“Together we Understand” in Hebrew), a platform that uses AI to present a doctor, with an entire in-depth medical history that they can read and digest in two minutes.
It presents them with indications of risk factors, illnesses, and treatments of a patient, in an easy-to-read patient profile that can be accessed through a smartphone app. So they no longer need to trawl through a mass of records going back months and years from different hospitals and different specialists.
The company was founded by two former intelligence officers who revolutionized the use of AI during their time in the IDF to present military commanders with the data they needed, when they needed it.
They are now adapting that model to help busy doctors who need to have all relevant data at their fingertips the moment their patient walks into the surgery.
Navina says it turns “chaotic data into actionable patient portraits”. The portrait replaces disorganized patient data with a logical grid that makes it possible for a primary care physician to access a patient’s medical records within seconds.
Navina’s patient portrait provides a one-page summary with critical information from many sources, including images, emails, and faxes that are hard for physicians to find on their own.
The team teaches the machine how to extract the proper data no matter what the source. To do this, Navina developed NLP (natural language processing) models which extract and structure the data through deep learning. with special codes for specific terminology.
Ronen Lavi, co-founder and CEO of Navina, compares the profile to what happens when you do a Google search on a person, where clicking to search will get you a page that is a roundup of the person with a photo, biography, information about life experiences, and articles correlated with the person. Similarly, Navina would present a contextual summary of a patient’s most pertinent medical information so that physicians can understand their health status.
Navina presents the doctor with a two-minute in-depth patient profile. Deposit Photos
“We built algorithms to do two main things. First, you have a lot of unstructured data — a lot of text. In a process called entity extraction, we extract all the right relevant codes out of the text, all the labs, all the meds, all the problems, all the diagnoses, through machine learning (ML) capabilities. Then, we build a knowledge graph that links all the data,” he tells NoCamels.
“For a problem like blood pressure, [the profile] will show you the right medication, the right consult notes, the right lab tests, everything is correlated and explained to the physician. That’s the two main things we’re doing behind the scenes,” he says, noting that it’s about taking all the information, doing a correlation, and then creating a link that gives you a contextual understanding of your subject.
“What we saw was one of the main problems of physicians. They can address one or two problems — maybe three — if they know them in advance,” Lavi adds. “Five minutes before having to leave, the patient remembers – ‘Oh, hey, I have to ask you about this medication. I have to ask you about the new problem I have. I have to ask you about my family — and the physician hates this. The patient also hates it because they get the answer, ‘Sorry, my friend, I can’t deal with this right now. I have to go to the next meeting. And the patient doesn’t get the full attention he needs.”
The Navina app is currently being used by some 1,500 physicians and at leading clinics across the United States. The company is also marketing the product to health providers and risk adjustment teams , that predict future health care expenditures of individuals based on diagnoses and demographics.
Cutting through the clutter of patient data
The healthcare industry has amassed a huge amount of data over time, which has quickly become disorganized and difficult to manage. With so much data to analyze so quickly, health professionals often turn to AI to organize and interpret the data for improved insights.
This isn’t easy, Lavi tells NoCamels. In fact, it’s “complicated technology,” which explains why it hasn’t been done before. But Navina has a number of AI and medical experts on its team, including two co-founders with experience in the elite 8200 unit of the IDF, where they focused on bringing AI from theory into practice.
Lavi spent 24 years in 8200 and at the Prime Minister’s Office, where he established and led the AI Lab of Israel’s Military Intelligence, which collaborates with leading tech companies and academia to develop cross-functional platforms that provide insight into challenging data. Shay Perera, CTO at Navina spent a decade in elite intelligence units, where he was involved in R&D and held leadership positions. He also has a Master of Science in electrical engineering from the Technion with a specialty in machine learning.
Perera says a relative of his was diagnosed very late with cancer due to mistakes by the family doctor and his condition deteriorated as a result. The pair realized GPs were missing out on many critical diagnoses because they couldn’t absorb the volume of patient data they had to deal with.
The Navina team behind the app that turns chaotic data into clear information for doctors. Courtesy
Lavi and Perera were responsible for one of the greatest revolutions that took place in 8200 and later in the IDF – the smart data revolution that is presented to commanders in real-time. The two built the AI / ML-based information systems of the cyber units that processed data and upgraded the capabilities of cyber commanders and won a National Security Award for their efforts in 2018.
After being released from the army, the two used their knowledge and expertise in data, AI, and machine learning to make a difference in people’s lives. For Naviana, founded in 2018, the two replicated the data model they built in the IDF to implement it in health institutions around the world.
“I think the gain for the patient is very obvious,” says Lavi, “They want to get everything to be addressed. And the physician should be with the patient, not with the computer. And that’s what Navina allows them to do because everything’s summarized for you in two or three clicks.”
“Navina is disruptive because it’s one of the first digital health applications that I know of, which the physician is actually willing to use. It’s not a burden. The machine behind the scene does a lot of stuff for them that allows them to understand the patient very easily. And every time I say that, people ask how did nobody think about it before and why hasn’t it been done.”
Funding will be used to support more than a dozen studies
A new university grant program in Israel with a budget of over $1 million will support researchers in their quest for new food technologies.
The ministries of Agriculture and Innovation, Science and Technology initiated the program with an emphasis on alternative proteins.
The ministries launched a call for proposals last Thursday, in collaboration with the Good Food Institute (GFI) Israel, a non-profit organization that seeks to promote research and innovation in food technology.
The food technology sector is a broad field that includes nutrition, packaging, food safety, processing systems, new ingredients and alternative proteins. These include plant-based meat, dairy and egg substitutes, dairy products, cultured meat and seafood, insect proteins, and fermentation products and processes.
Many of the technologies used in this field are based on academic research.
The technologies of two major Israeli cultured meat companies, Aleph Farms and Future Meat, are based on bioengineering research developed by their respective co-founders, Professor Shulamit Levenberg of the Technion – the Israel Institute of Technology – and Professor Yaakov Nahmias of the Hebrew University of Jerusalem.
Both are leading academics in the field of tissue engineering.
Ministry funding will support a dozen university studies offering science and technology solutions in the areas of cultured meat, fermentation processes and plant-based substitutes.
These studies can be aimed at improving the final product or the production process itself, the ministries said.
