Overall effectiveness of coronavirus vaccines has not dropped much yet for most vaccinated Americans, US Centers for Disease Control and Prevention vaccine advisers were told Monday.
CDC’s Advisory Committee on Immunization Practices met Monday to discuss the potential eventual need for booster doses of coronavirus vaccine — although they did not vote. The White House has said it’s planning to offer booster doses at the end of September, although it’s up to the US Food and Drug Administration and the CDC to decide on this.
So far, in data that goes through July, the vaccines still appear to provide strong protection, the CDC’s Dr. Sara Oliver told ACIP Monday.
“Since the introduction of the Delta variant, VE against infection ranges from 39 to 84%. VE against hospitalization, though, remains high from 75% to 95%,” Oliver said, citing global data.
“Regardless of the vaccine evaluated, all vaccines remain effective in preventing hospitalization and severe disease. But they may be less effective in preventing infection and mild illness recently,” Oliver added. “These reasons for lower effectiveness likely include both waning over time and the Delta variant.”
One US study showed vaccine effectiveness against hospitalization in adults 65 and older may have decreased, but only slightly, over time, she said. Unpublished CDC data shows vaccine effectiveness remains very high, at 94% or higher in adults 18 to 74, she said.
“Preliminary VE against hospitalization in adults 75 years of age and older … decreased in July but still remained over 80%,” Oliver said.
Vaccine efficacy has fallen from 75% at first to just over 50% among long term care facility residents, Oliver said. These were the first people vaccinated after the shots became available in December and January.”
The data we have seen today has demonstrated that Covid vaccines continue to maintain high protection against severe disease, hospitalization and death. Protection against infection, including asymptomatic and mild infection, appears to be lower in recent months,” she said.
All three companies making vaccines for the US market — Pfizer/BioNTech, Moderna and Johnson & Johnson — are evaluating the effects of booster doses, she said.
The major questions are whether booster doses are safe and work to improve protection, she said.
“Will booster doses of Covid-19 vaccines reduce Covid-19 incidence, hospitalization and/or mortality?” she asked.
ACIP will meet in the coming weeks to discuss data about vaccine efficacy in August, Oliver said. “We will announce meetings as soon as we have dates,” the CDC’s Dr. Amanda Cohn said at the end of Monday’s meeting.
The CDC and FDA endorsed the use of boosters in certain immunocompromised people earlier this month. While the White House has pressed for booster doses to be offered more widely, the CDC and FDA are waiting for more information from the companies.
But White House officials say they’re looking at data from Israel as well as from the US, and want to be sure to be ahead of any changes in the pandemic.
On Monday, Israel started offering a booster to everyone 12 and older who had been vaccinated at least five months ago.
Researchers in Israel reported Monday that people who chose to get a third dose of vaccine had a much lower risk of becoming infected, even as the more transmissible Delta variant swept across the country.
“Conclusions: In conjunction with safety reports, this study demonstrates the effectiveness of a third vaccine dose in both reducing transmission and severe disease and indicates the great potential of curtailing the Delta variant resurgence by administering booster shots,” Yair Goldberg of the Technion-Israel Institute of Technology and colleagues wrote in their report, posted online by the Israeli government.
The researchers noted that it is difficult to account for differences among people in a real-world study. People who choose to get a booster dose may be different from those who choose not to, and people behave differently after they’ve received a shot.
One major difference: recently vaccinated people are less likely to be tested for coronavirus infection, which means fewer infections would be detected in that group. Recently vaccinated people may also take more care to prevent infection.
These biopolymers can be used for solar energy generation, medicine, biomedical engineering and more. * They are affordable and are a viable alternative to petroleum-based polymers.
Researchers at the Technion-Israel Institute of Technology have been advancing a groundbreaking technology that allows for converting food byproducts into energy-conductive biopolymers.
These biopolymers are, essentially, based on recycled food industry byproducts that would otherwise have been thrown away as waste. However, it is possible to convert them into biopolymers that can be used for solar energy generation, biomedical engineering and more.
The Technion’s approach is a combination of two main approaches, environmental chemistry and sustainable chemistry. The former deals with creating environmentally friendly materials and the latter uses available degradable materials and an energy-efficient process.
Essentially, what the researchers did was use an environmentally friendly production process for the purpose of creating environmentally friendly materials and products, specifically polymers.
Polymers themselves are long chains of various different building blocks, which are, fittingly, called monomers. These can be formed naturally, such as silk and cotton fibers, and synthetically, such as nylon.
But conductive polymers are a specific subgroup that have a vast number of possible applications, ranging from electronics to fuel cells to medicine and more. However, creating them is very costly, and having to use derivatives of gas, oil and fossil fuels means they also cause pollution.
But the Technion researchers have found an alternative with their focus on using food industry byproducts, which they have dubbed protein polymers.
“The inspiration to use proteins to create conductive polymers originated in the unique function of proteins in nature – they are exclusively responsible for transporting various charge carriers in flora and fauna; for example, in cellular respiration or in photosynthesis in plants,” lead author Prof. Nadav Amdursky of the Schulich Faculty of Chemistry said in a statement.
The transparent biopolymer films created by the researchers have a high degree of conductivity. As they are natural and non-toxic, it can be used for biological and biomedical applications. It can be stretched to around 400% of its original length without significantly impacting its electrical properties, and its conductivity is some of the highest found in biological materials.
“The production of the film in our research was a one-pot process, spontaneous, inexpensive, fast, energy efficient, and nonpolluting,” Amdursky explained. In their study, which was published in the academic journal Advanced Materials, “we demonstrate the use of the film as ‘artificial skin’ that noninvasively monitors electrophysiological signals. These signals play a meaningful part in brain and muscle activity, and therefore their external monitoring is a highly important challenge.”
These findings are significant not only for the scientific and environmental implications of this method, but also the economic aspect.
The method is affordable, and has a low production cost, something that Abdursky emphasized as being important as it allows the product to be something that can viably compete on the market with the petroleum-based polymers that currently dominate the field. That way, with the technology more accessible, it can become more widespread and help reduce pollution.
ISRAEL RECYCLES NATURAL POLYMERS FROM THE FOOD INDUSTRY FOR A VARIETY OF PRODUCTS AND PROCESSES
Hashem took the man and placed him in the garden of Eden, to till it and tend it.
Genesis 2:15 (The Israel BibleTM)
A tremendous amount of packaging waste is thrown out by the food industry all around the world and in Israel as well. But they can – and should be recycled for reuse.
Scientists at the Technion-Israel Institute of Technology in Haifa have just published details in the journal Advanced Materialsunder the title “A Protein-Based Free-Standing Proton-Conducting Transparent Elastomer for Large-Scale Sensing Applications” about their success in creating conductors that can be used for solar energy generation, biomedical engineering and more using by-products of the food industry.
The technology they presented makes possible the simple, fast, cost-effective and environmentally friendly production of biopolymers, which include application for electrophysiological signal sensing.
Polymers are materials made of long, repeating chains of molecules an d have unique properties depending on the type of molecules being bonded and how they are bonded. Synthetic polymers include plastics, that use costly processes that cause pollution because they are made from derivatives of oil, gas and fossil fuel.
Biopolymers are natural polymers produced by the cells of living organisms. Among the natural ones are collagen, fibrin, starch, hair, fur, nails, cotton, gelatin, natural rubber, cellulose, wool and silk (created by silkworms).
Polypeptides such as collagen and silk are inexpensive biocompatible materials that are being used in groundbreaking research, as these are easily attainable materials. Gelatin polymer is often used on dressing wounds as an adhesive. Scaffolds and films with gelatin allow for the scaffolds to hold drugs and other nutrients that can be used to supply to a wound for healing.
Another widely used biopolymer is chitosan derived from the exoskeleton of crustaceans and insects, it can biodegrade which can eliminate a second surgery for implants, can form gels and films/ Ot cam also be used to improve drug absorption and stability and for gradual release of anti-cancer drugs.
In the food industry, biopolymers that are transparent. Biodegradable and water resistant are being used not only for packaging but also for edible encapsulation films and the coating of foods.
The Technion study was conducted in the Schulich Faculty of Chemistry under the leadership of Assistant Prof. Nadav Amdursky, head of the biopolymers and bioelectronics laboratory, and doctoral students Ramesh Nandi and Yuval Agam. “The current global green trend has not bypassed industry, and numerous groups worldwide are working on new solutions that will limit the pollution caused by the production of synthetic materials and by their very presence,” explained Amdursky. “One of the options is, of course, the use of natural materials, and the big challenge is to adapt them to meet needs.”
The two main approaches in environmentally conscious chemistry are environmental chemistry (the creation of environmentally friendly materials) and sustainable chemistry (production based on available degradable materials and energy-efficient processes). The new research integrates the two approaches in an environmentally friendly production process that yields environmentally friendly products in the context of conductive polymers.
The protein polymers used by the Technion researchers are by-products of the food industry that would otherwise be thrown into the garbage. “The inspiration to use proteins to create conductive polymers originated in the unique function of proteins in nature – they are exclusively responsible for transporting various charge carriers in flora and fauna; for example, in cellular respiration or in photosynthesis in plants,” he continued.
The researchers created transparent polymer films with high conductivity. This film is suitable for biological and biomedical applications since it is non-toxic and can be stretched to approximately 400% of its original length without significantly impairing its electrical properties. Its conductivity is among the highest detected in biological materials.
The team used bovine serum albumin (from cows), one of the most affordable proteins that results in the ability to create large-scale materials at a low cost. Due to the inherent biodegradability and biocompatibility of the elastomer, it is promising for biomedical applications, he said, and it can be used immediately as a solid-state interface for sensing electrophysiological signals,
“The production of the film in our research was a one-pot process, spontaneous, inexpensive, fast, energy efficient and nonpolluting,” said Amdursky. “In the article, we demonstrate the use of the film as ‘artificial skin’ that noninvasively monitors electrophysiological signals. These signals play a meaningful part in brain and muscle activity, and therefore their external monitoring is a highly important challenge.”
He stresses that since this technology is designed for application and commercialization, “the economic consideration is key, and consequently, it is most important to lower the costs of production processes so that they will yield a product that is competitive, also in terms of price, with petroleum-based polymers, and happily, we have succeeded. This is in addition to the reduction in environmental damage in the production phase as well as during use. The new polymer is fully biodegradable in less than 48 hours, as opposed to synthetic polymers, which are not biodegradable and as result, pollute our planet.”