Celebrate Pi Day and read about how this number pops up across math and science on our special Pi Day page.

For more than two millennia, mathematicians have produced a growing heap of pi equations in their ongoing search for methods to calculate pi faster and faster. The pile of equations has grown into the thousands, and algorithms now can generate an infinitude. Each discovery has arrived alone, as a fragment, with no obvious connection to the others. But now, for the first time, centuries of pi formulas have been shown to be part of a unified, formerly hidden structure.

Divide any circle’s circumference by its diameter and you get pi. But what, exactly, are its digits? Measuring physical circles won’t tell you—your tools are too clunky to discover pi’s endless numerals. Uncovering its true value requires something much more powerful: a formula.

It all started with Archimedes, who developed the world’s first known mathematical proof for pi’s value. He thought of a circle as an infinite-sided polygon with sides of zero length. The math to handle infinitesimals (calculus) wouldn’t arrive for another 1,900 years, so instead he circumscribed 96-sided polygons on the outside and inside of a circle and used geometry to calculate their perimeters. He was able to determine that pi fell somewhere between 3.140845… and 3.142857…, trapping it in a range. His rigour stood for 1,600 years.

Then, around the 14th century, Indian mathematician Madhava of Sangamagrama provided the first exact formula, expressed as an infinite series—a sum of endlessly many terms that, if you could somehow add them all up, would yield pi exactly. The catch: his series converged agonizingly slowly, requiring hundreds of terms just to nail down a few decimal places. More than three hundred years later Leonhard Euler discovered another series that converged faster. And in the early 1900s, the mathematician Srinivasa Ramanujan produced formulas that are still revered for their efficiency today.

Graphic shows four examples of formulas for pi and lists each formula’s associated author, the author’s country of origin and the year in which the formula was first discovered or published.
Amanda Montañez; Source: “From Euler to AI: Unifying Formulas for Mathematical Constants,” by Tomer Raz et al. Preprint posted November 16, 2025 to https://arxiv.org/pdf/2502.17533 (reference)

Each equation seemed unrelated to the others. But in late 2025, a team of seven AI researchers at the Technion–Israel Institute of Technology found a previously unknown mathematical structure underlying hundreds of pi formulas, including those of Archimedes, Euler and Ramanujan. “It’s not every day that you get to cite Archimedes,” says Ph.D. student Michael Shalyt, part of the team. The structure, called a conservative matrix field, or CMF, acts as a kind of mathematical common ancestor, showing how formulas that look nothing alike turn out to be different expressions of the same underlying object.

The project grew out of group head Ido Kaminer’s 2019 Ramanujan Machine, an AI bot that seeks out new conjectures for calculating mathematical constants. Anyone can download the software for free, and many have used it to find new pi formulas to join the heap. The bot’s unconventional approach was a viral success, if not taken entirely seriously by mathematicians. “When we started doing AI research in this area of math,” Kaminer says, “it was seen as a fringe idea.”

But as the machine and other mathematicians kept churning out formulas, eventually the question became unavoidable: Were any of them connected?

The group, who also have backgrounds in areas such as physics and math, approached the problem like experimentalists and decided to gather a dataset. Tomer Raz, then a master’s student at Technion, wrote code to download every math paper that had ever been uploaded to the preprint server arXiv.org, running his laptop seven days a week, 24 hours a day, for six weeks to download 455,050 papers at a slow enough rate to respect the website’s limit.

The group then deployed GPT-4o in combination with specialized algorithms to detect pi-related equations, translate them into executable code, and remove trivial duplicates. From nearly half a million papers, they extracted 385 unique formulas, including about 10 percent that originated from the Ramanujan Machine.

For the next step, they recast the 385 equations into the same format—a special type of infinite series. But the expressions still all converged to pi, leaving no obvious way to compare them. Something deeper was needed.

That something was the CMF, which some members of Kaminer’s group had introduced in 2023. Shalyt calls it a Swiss army knife for mathematics. “It can unify 2,000-year-old formulas [and] give hierarchy for constants in math, and we hope to [use it to] prove some properties of irrationality related to the Riemann hypothesis,” he says.

Think of the CMF like gravity defined on a grid. Each pi formula traces a different path across the grid. Just as a gravitational field guarantees that the energy difference between two points is the same, regardless of route, the CMF guarantees that only the destination matters. From this single constraint, something remarkable emerges: when two pi formulas trace parallel paths through the same CMF grid, they are equivalent (one can be transformed into the other), however mismatched they appear on the surface.

The group derived the CMF of pi, then used algorithms to see where each formula fit inside the grid, finding clusters of similar equations. An algorithm formally proved whether a cluster of equations belonged to the CMF. The result: 43 percent of all known pi formulas descend from a single CMF. Another 51 percent belong to broader clusters. (The researchers are still working out their precise relationships.) Only 6 percent of the formulas remain orphans, with no proven connection to anything else.

It’s an open question whether a more complex CMF could capture the entire set, Kaminer says. Another open question is whether every single equation generated from the CMF is a pi formula—so far, all the equations the team has tried have worked.

David Bailey, a retired computer scientist formerly at Lawrence Berkeley National Laboratory, who wasn’t involved in the study (though a pi formula bears his name and the group used one of his algorithms), says the project’s results are as if 17th-century chemists had been discovering atomic elements one by one “and then all of a sudden, someone let loose a computer program that constructed the whole periodic table automatically.”

Mathematician George Andrews, a professor emeritus at the Pennsylvania State University (who famously uncovered a lost trove of Ramanujan’s notes) had previously criticised the group for naming their machine after Ramanujan. But he had nothing but praise for the current work. “This is serious mathematics done in a serious way,” he says. “More and more surprising things should emerge.”

Belgian-born Technion scientist Dr. Katrien Vandoorne leads research tracking inflammation in the body and says Israel’s collaborative science culture and wartime resilience convinced her to build her lab and raise her family here

When Dr. Katrien Vandoorne first arrived in Israel to pursue her PhD at the Weizmann Institute of Science, she was struck by something that went far beyond laboratories and research facilities. “The people were very collaborative and warm and inspiring,” she recalled. “The science was really great for me, but also the Mediterranean climate, the food, all those things.”

Originally from Belgium, Vandoorne said the country’s scientific culture felt very different from the academic environment she had known in Europe. “In Belgium it’s very hierarchical,” she said. “The professor is very high up, and you should always be very polite and never question anything that is written in the book.”

How did you find Israel’s scientific culture in contrast?
“What I really like about Israel is that, as a master’s student, you can question the whole theory of your professor, and there is no problem with that,” she said. “Your professor will actually like it that the student is engaged and wants to make your theory fall.”

For Vandoorne, that openness was transformative. “No one will ever say, ‘That’s a stupid question,’” she said. “Everybody will say, ‘Hey, that’s a good question,’ and take it as a sport.” She believes this atmosphere encourages creativity and innovation. “The young people, they’re the ones with the, maybe, crazy ideas, but maybe also really solving things that the previous generations couldn’t solve.”

Building a life in Israel

Although Vandoorne later had opportunities to work in Europe and the United States, she and her family ultimately decided to build their future in Israel. “It was really a package deal,” she said. Her husband, an Israeli, had long hoped to return. But Vandoorne said the decision was not only personal. “For me it was really the scientific culture and the unique combination of very good science that wants to make an impact and solve problems, together with a really human environment,” she said.

Dr. Katrien Vandoorne
Dr. Vandoorne having breakfast with her students on the grass next to the faculty building: coffee, ideas, and a little team-buildin (Photo: Private album)

Family considerations also played a central role. The couple moved to Israel in the summer of 2018 with their three young children. “They were 3, 5 and 7,” she said. Starting over in a new country while raising a family was not simple. “Becoming an immigrant means that you have to learn the language, find new friends and also professionally grow,” she said. “It’s been a journey.”

Despite the challenges, she says the experience has been enriching. “Instead of making myself smaller by being only an immigrant, I expanded myself by learning Hebrew and also being part of the Israeli culture,” she said.

Mapping inflammation in the body

Today Vandoorne is head of theIn Vivo Multi-Scale Imaging Lab at the Technion’s Faculty of Biomedical Engineering in Haifa. Before joining the Technion, she worked at leading research institutions in Europe and the United States, including Eindhoven University of Technology in the Netherlands, and conducted research at the Weizmann Institute of Science, where she completed her PhD.

Her team studies how inflammation spreads through the body and how immune cells travel between organs. “When the body faces any stress like infection, chronic disease or heart attack, the immune system is activated,” she explained. “Most of these immune cells come from the bone marrow. It’s like a factory inside the bones where blood and immune cells are produced.” Her work focuses on how inflammation contributes to diseases such as heart disease, diabetes and neurological disorders, conditions in which the immune system plays a key role.

Dr. Katrien Vandoorne

Using advanced imaging technologies including MRI, PET-CT and intravital microscopy, her team tracks immune cells as they move from the bone marrow through the bloodstream to organs such as the heart and brain. “Our goal is really to visualize these inflammatory processes so we can measure them, monitor them and ultimately also treat them,” she said. “Or even diagnose them earlier and be more precise with therapies.”

Vandoorne’s work sits at the intersection of biology, medicine and engineering, reflecting the Technion’s approach of combining technological innovation with medical research.

A unique research ecosystem

Vandoorne says the Technion’s strength lies in its ability to bridge engineering and medicine. “It combines engineers on the technical side and clinicians on the medicine side,” she said. “You have Rambam Hospital, a great medical school and all the engineers needed to solve problems.” Biomedical engineers often stand at the intersection of those disciplines. “We’re really trying to work on real-world problems,” she said.

Dr. Katrien Vandoorne

Beyond infrastructure, she credits the university’s collaborative atmosphere. “It’s a very warm human environment,” she said. “Everybody is open and supporting. Whatever question I have, people are trying to help.”

Life and work during war

Like many Israelis, Vandoorne’s daily life has also been shaped by the ongoing war. “The war has been a rough pill to swallow,” she said. Without extended family nearby and with many international friends leaving Israel after the October 7 attacks, the experience has been emotionally challenging. “I built up a whole network of friends and most of them left,” she said. “It was very confronting for me to need to start it up again.”

Yet she says both her children and her students have helped her navigate the uncertainty. “My children teach me the most about how to deal with it,” she said. “I worry about them and they tell me not to. They say they are fine.” Her lab community has also provided support. “For me our faculty feels like a small family,” she said. “Everybody is really part of the community.”

Dr. Katrien Vandoorne

During periods of heavy rocket fire from Hezbollah in northern Israel, staff and students often gathered in a large underground shelter inside their building. “We were just all down there trying to ground ourselves by talking science in the shelter while bombs were falling,” she said. “After everything stops everybody gives a hug and we go back up and continue our day.”

Believing in Israel’s scientific future

Despite the difficulties, Vandoorne remains optimistic about Israel’s future in science and innovation. “I think if anywhere there’s going to be biomedical innovation, it’s going to be here,” she said. Part of that belief comes from what she sees as a national resilience. “We are not afraid of anything,” she said. “That lack of fear stops many people in other countries from innovating.”

Dr. Katrien Vandoorne

Facing constant challenges can also fuel creativity, she said. “If you are in a country where everything is good and everything is fine, you don’t want to take a challenge,” she said. “Here we deal with challenges every day.”

For Vandoorne, that spirit continues to shape both her research and her life in Israel. “It really feels like a place where people want to solve problems and help each other,” she said. “That’s why I want to stay.”

Prof. Katrien Vandoorne is head of the In Vivo Multiscale Imaging Lab in the Faculty of Biomedical Engineering in the Technion – Israel Institute of Technology.

The Technion claimed the top spot in Europe for AI research according to CSRankings, placing 21st globally, and has fuelled a surge of successful commercial tech spinoffs.

The Technion Israel Institute of Technology was ranked the best university in computer science and artificial intelligence research in Israel and Europe. It was also ranked 21st worldwide, according to an index unveiled by CSRankings on Monday.

The index was created using the number of peer-reviewed conference papers published by Technion researchers between 2005 and 2025 at the world’s leading computer science conferences, highlighting the Technion as one of the leading institutions in AI research and development.

The institute was also ranked among the top ten most important universities when investigating Machine Learning, a subfield of Artificial Intelligence.

The Technion explained that this achievement was possible thanks to its extensive community of researchers, comprising more than 150 professionals from across a range of faculties, working in various areas of AI research and development.

“This international recognition stems from a long-term strategy to advance AI research at the Technion and from substantial investment in this field,” said Prof. Danny Raz, Senior Executive Vice President at the Technion.

Aerial view of the Technion Israel Institute of Technology (credit: TECHNION SPOKESPERSON’S OFFICE)

“Hundreds of our faculty members apply advanced AI-based methods across a wide range of fields, including data science, medical research, mechanical engineering, civil engineering, architecture, and biology, and I am confident this trend will only intensify,” he added.

Technion transforms academic achievements into commercial applications

According to a statement by the institute, the Technion’s AI research achievements have been translated into commercial applications, mainly using the T3, the Technion’s technology transfer arm.

Among the most important are Firefly Neuroscience (brain health), founded by Dr. Shahaf Goded and which went public in 2024; DECI AI (deep learning), founded by Prof. Ran El-Yaniv and acquired by NVIDIA; and Autobrains (autonomous vehicles), founded by Prof. Yehoshua Zeevi.

Other important companies founded by Technion’s alums are Barcode Nanotech (in-body particle transport for therapeutic purposes), founded by Prof. Avi Schroeder, Pickommerce AI Robotics (robotics), founded by Prof. Elon Rimon, Nol8 (data processing), founded this year by Prof. Mark Silberstein, Metasight Diagnostics (bioinformatics), founded by Prof. Tomer Shlomi, and SleepAI (sleep research), founded by Prof. Joachim Behar.

Patent registration involves prestige as well as significant money. Commercial companies file patents and reap major profits, but academic institutions also benefit from the innovations developed by their researchers.

Israel holds a respected position in this arena, and for the fifth consecutive year, the Technion – Israel Institute of Technology ranked among the Top 100 institutions for U.S. patent approvals.

The latest ranking places the Technion first in Israel, second in Europe, and within the list of the world’s 100 leading institutions for U.S. patent approvals in 2025. The Technion ranked 81st globally, with 46 patents approved during the year, and was the only Israeli university to make the Top 100. The top spot went to the governing body of the University of California.

The Technion’s approved patents span a wide range of fields, from artificial intelligence to 3D-printed structures, from smart drug delivery systems to advanced materials and quantum computing technologies.

Prof. Yuval Grofeni, Deputy President for Innovation and Industry Relations, said: “The Technion’s continued success at the forefront of patent approvals is a credit to our faculty members and their students, who constantly strive for excellence. Many invest not only in high-level research but also in translating their work into technologies and products that positively impact quality of life.”

The patent rankings are published by the National Academy of Inventors (NAI). The organization notes that U.S. patent registration enables academic and other institutions to convert original technologies into competitive products in the global market and make a tangible impact on consumers. The NAI ranking is based on data from the United States Patent and Trademark Office (USPTO) for 2025 and includes 100 institutions and approximately 10,000 patents.

Rona Samler, CEO of T3, the Technion’s technology transfer unit responsible for patent evaluation and licensing, added: “Behind every patent stands deep scientific thinking, and behind every licensing decision — responsibility for generating real-world value. T3 is tasked not only with managing patents but also with transforming knowledge into innovation through commercialization and company formation, thereby serving society, strengthening the economy, and contributing to the resilience and prosperity of Israel and the world.”

A research team from the Technion’s Wolfson Faculty of Chemical Engineering has developed an original technology for treating cancer using nanoparticles that carry no drugs at all, and has demonstrated its effectiveness against particularly dangerous and stubborn tumors

An innovative technology developed by researchers at the Technion-Israel Institute of Technology could lead to a fundamental shift in the cancer treatment paradigm. They created advanced nanoparticles that successfully halt aggressive triple-negative breast cancer tumours – without releasing a single drug molecule. The particles operate through a sophisticated interaction with the immune system, changing the rules of the game by delivering a biological message to the tumour microenvironment and to immune system cells.

Published in ACS Nano, the study was led by Ph.D. candidate Ofri Vizenblit, with the assistance of Ph.D. candidate Rawan Mhajne, under the supervision of Assistant Professor Assaf Zinger, head of the Bioinspired Nano Engineering and Translational Therapeutics Laboratory in the Wolfson Faculty of Chemical Engineering.

Triple-negative breast cancer is considered one of the most aggressive and difficult cancers to treat. It is characterized by rapid progression and high resistance to conventional therapies. The new paradigm change presented by Technion researchers is based on a revolutionary approach: instead of attacking the cancer cells themselves, it targets the environment in which they exist and develop.

Cancer cells employ a range of “strategies” to evade the immune system, which is supposed to identify and destroy them. One of the central strategies is recruiting immune cells to their side. In such cases, white blood cells known as macrophages –whose role is to protect the body – are “hijacked” by the tumour, support its growth, and prevent the immune system from attacking it effectively.

The nanoparticles developed by the Technion researchers, called MPsomes, act as a biological decoy. They compete with immune cells for binding sites in the tumor microenvironment and block the access of harmful cells to the tumor. The particles were tested in cell cultures and in preclinical mouse models of triple-negative breast cancer. The experimental results showed that the particles accumulate in exceptionally high concentrations around the tumor and inhibit its growth with effectiveness comparable to that of existing treatments.

An additional advantage highlighted by the researchers is manufacturability: the process developed at the Technion enables the production of approximately 20 ml of nanoparticles per minute (about 1.2 liters per hour). Moreover, the particle base is composed largely of materials that are recognised by the FDA as Generally Recognised as Safe (GRAS), a factor that may facilitate the transition to clinical trials and ultimately to medical use.

The results were particularly surprising: in pre-clinical experiments, the particles not only accumulated in the tumor but also inhibited its growth like the effects of advanced immunotherapies currently approved for clinical use, all without drugs, without chemotherapy, and without antibodies.

“This is a conceptual shift,” the researchers explained. “The therapeutic efficacy does not stem from the release of an active substance, but from the biological information encoded on the surface of the nanoparticle.” In other words, it is the interaction with the immune system itself that triggers the therapeutic effect.

Beyond inhibiting tumour growth, the researchers showed that the particles alter the composition of immune cells in the tumour environment: fewer cells that promote tumour development and more cells that attack it. In addition, no signs of toxicity were observed in vital organs.

The research is still at the preclinical stage and has so far been tested only in mouse models. Nevertheless, the researchers hope that in the future it will be possible to advance to clinical trials in humans and perhaps open the door to a new generation of cancer therapies, ones that do not rely on drugs at all.

Assistant Professor Assaf Zinger earned his bachelor’s degree from the Technion Faculty of Biomedical Engineering and his Ph.D. from the Wolfson Faculty of Chemical Engineering. He returned to the Wolfson Faculty as a faculty member in October 2021 after completing a postdoctoral fellowship at Houston Methodist Hospital in Texas. Ofri Vizenblit, also a graduate of the Technion Faculty of Biomedical Engineering, joined Zinger’s laboratory immediately after completing her bachelor’s degree, and the current paper is part of her doctoral research. “Although we focused here on a specific type of cancer,” concluded Dr. Zinger, “this is a paradigmatic breakthrough that can lead to the development of new therapeutic platforms that are more effective and safer. I sincerely hope we will find the path to bring this invention to the clinic.”

The research was supported by the Israel Cancer Research Fund (ICRF), the Israel Science Foundation (ISF), the European Union (ERC Starting Grant), the Ministry of Innovation, Science and Technology (MOST), the Israel Cancer Association, the Russell Berrie Nanotechnology Institute at the Technion, and the Alon and Seiden Fellowships in nanotechnology and optoelectronics.

Technion and top US universities unveil implantable ‘living pancreas’ that senses glucose, produces insulin and evades immune response, paving the way for self-regulating, long-term diabetes treatment without daily injections

A multinational research team led by an Israeli engineer and involving top U.S. universities has unveiled a pioneering implantable device that could someday eliminate the need for daily insulin injections for people with diabetes.

The study, published Jan. 28 in Science Translational Medicine, describes a living, cell‑based implant that functions as an autonomous “artificial pancreas.” Once placed in the body, the device continuously monitors blood glucose levels, produces insulin internally and releases exactly what the body needs — without external pumps, injections or patient intervention.

The breakthrough centers on a novel protective technology researchers call a “crystalline shield”, engineered to prevent the body’s immune system from rejecting the implant — a major hurdle that has stymied cell‑based therapies for decades. The shield allows the implant to operate reliably for years.

Tests in mice showed effective long‑term glucose regulation, and studies in non‑human primates confirmed that the cells inside the implant remain viable and functional, the researchers said. Those results, they added, provide strong support for future clinical testing in humans.

The work was led by Assistant Professor Shady Farah of the Technion — Israel Institute of Technology’s Faculty of Chemical Engineering, in collaboration with scientists at the Massachusetts Institute of Technology, Harvard University, Johns Hopkins University and the University of Massachusetts. The collaboration traces back to Farah’s postdoctoral work beginning in 2018 at MIT and Boston Children’s Hospital/Harvard Medical School, under tissue‑engineering pioneers including Robert Langer, a co‑founder of Moderna.

Assistant Professor Shady Farah
Assistant Professor Shady Farah

Farah’s co‑first authors on the paper are Matthew Bochenek of MIT and Joshua Doloff of Johns Hopkins. Other contributors include Technion researchers Dr. Merna Shaheen‑Mualim and former master’s students Neta Kutner and Edward Odeh, who also helped adapt the work for publication.

While the initial focus is on diabetes, the team emphasized that the platform could one day be adapted to deliver other biologic therapies continuously, offering a new approach to chronic conditions such as hemophilia and other metabolic or genetic diseases.

If successfully translated into human treatment, experts say the technology could reshape the management of chronic illness by replacing lifelong drug regimens with self‑regulated, living therapeutics working continuously inside the body.

What if a single breath — or a small wearable patch — could reveal disease long before symptoms appear? For years, Prof. Hossam Haick of the Technion – Israel Institute of Technology has been turning that revolutionary idea into a reality. By identifying invisible chemical signals emitted by the human body, Prof. Haick has helped transform how illness can be detected: faster, earlier, and without invasive tests.

Global Recognition for Transformative Innovation

His pioneering research has opened new paths for diagnosing cancer, neurological disorders, infectious diseases, and more — using breath, skin, and advanced sensing technologies rather than needles or radiation. That life-changing work has led to Prof. Haick’s election as a Fellow of the U.S. National Academy of Inventors. This prestigious distinction is widely recognized as one of the highest professional honors for academic inventors worldwide, reflecting broad international recognition of Prof. Haick’s scientific achievements, groundbreaking inventions, and far-reaching impact on health care, technology, and education.

Prof. Haick is among a select group of researchers and inventors worldwide who have completed the full innovation cycle: from basic scientific discovery, through technological development, to real-world impact that touches the lives of millions.

In an academic landscape where basic and applied science are often separate, he stands out as someone who bridges the two worlds, translating deep scientific discoveries into clinical and technological tools with global influence.

His work led to the emergence of a new scientific field — volatilomics — which studies the chemical “fingerprints” the body emits through breath and skin.

A New Vision for Early, Noninvasive Diagnosis

This groundbreaking discovery has led to fast, noninvasive tests that give accurate results in just minutes and are used in medical centers worldwide. Additionally, Prof. Haick’s team has created smart patches that can monitor health from afar, along with new imaging tools that use chemical signals instead of radiation. These tools help doctors catch diseases early and provide personalized health care.

Beyond the Laboratory

Prof. Haick has also translated innovation into real-world impact. He holds dozens of patents and has founded several startup companies that bring advanced diagnostics, wearable devices, and electronic sensing technologies into practical use. He also founded and leads seven European Union research consortia, uniting more than 70 partners across four continents to accelerate the development and clinical adoption of advanced medical technologies.

Educating the Next Generation of Innovators

Equally significant is Prof. Haick’s role as an educator and mentor. He has published more than 500 scientific papers, authored two books, and supervised over 110 graduate and postdoctoral researchers, many of whom now lead research groups and technology companies of their own. His pioneering online course on nanotechnology and nanosensors — the first of its kind — has reached more than 1 million learners in 87 countries, extending Technion research and educational impact worldwide.

A Moment of Great Honor

Prof. Haick will be formally inducted into the NAI on June 4, 2026, at the Dolby Theatre in Los Angeles. During the ceremony he will receive a medal, certificate, lapel pin, and rosette from the NAI President and the representative of the United States Patent and Trademark Office. This extraordinary achievement reflects both Prof. Haick’s personal excellence and the Technion’s enduring mission to advance science that improves lives around the world.

Prof. Ido Kaminer and Prof. Yehonadav Bekenstein of the Technion have been awarded ERC Proof of Concept (PoC) grants by the European Research Council. The grants are expected to lead to a major leap forward in low-radiation medical imaging and in the precise mapping of biological tissues.

Two young researchers from the Technion have won the prestigious ERC PoC grants from the European Research Council (ERC). Proof of Concept grants are feasibility grants designed to promote the transition from academic research to application and commercialization, including the establishment of a startup company, and are awarded only to researchers who have previously received ERC grants. Grant amount: €150,000 each.

The two recipients are Prof. Ido Kaminer from the Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering and Prof. Yehonadav Bekenstein from the Faculty of Materials Science and Engineering. Both joined the Technion faculty in the same year, 2018, and in 2025 inaugurated a joint interfaculty laboratory: the Quantum Microscopy Lab. This innovative lab is equipped with state-of-the-art microscopes capable of detecting quantum phenomena that cannot be studied by other means. The laboratory, which also includes Dr. Michael Krüger from the Faculty of Physics, was established following the Technion’s success in a call issued by the National Authority for Technological Innovation, with support from the Helen Diller Quantum Center at the Technion.

Prof. Yehonadav Bekenstein, a graduate of the Hebrew University of Jerusalem, joined the Technion faculty after a Rothschild postdoctoral fellowship at the University of California, Berkeley. He is considered a leading scientist in materials discovery, specializing in light-emitting nanomaterials and perovskites  the technology at the heart of the new sensor that earned him the grant. His scientific work has been recognized with a series of prestigious awards, including the Krill Prize for Excellence in Scientific Research and the Goldberg Prize from the Technion.

The grant Prof. Bekenstein received will be used to advance MagicLayer a sensor for a new generation of medical imaging with minimal radiation exposure. The scientifc idea of the developed technology is based on nanocrystals and ultrafast quantum light emission.

3.המעבדה למיקרוסקופיה קוונטית בטכניון. מימין לשמאל : מנהל המעבדה ד"ר קובי כהן, פרופ' עדו קמינר , ד"ר מיכאל קרוגר ופרופ' יהונדב בקנשטיין.
The Quantum Microscopy Laboratory at the Technion. From left to right: Prof. Yehonadav Bekenstein, Dr. Michael Krüger, Prof. Ido Kaminer, and laboratory director Dr. Kobi Cohen

Sensors used in medical imaging are currently limited by their response speed. This relative slowness leads to the loss of valuable information and forces physicians to increase patients’ exposure to radiation. Standard crystals used in industry have reached the limits of their classical physical capabilities and struggle to deliver the field’s “holy grail,” which is a time resolution of 10 picoseconds. This is where the new sensor comes in; it is based on arrays of nanocrystals developed at the Technion. The light emitted from these arrays is correlated and responds significantly faster than existing technologies. The technology is relevant not only to medicine but also to improving electron microscopes and to real-time monitoring of radioactive gases in nuclear facilities. The research team behind the winning proposal includes Dr. Georgy Dosovitskiy, Dr. Rotem Strassberg, and Shai Levy.

Prof. Ido Kaminer, who completed all of his degrees at the Erna and Andrew Viterbi Faculty of Electrical Engineering, returned as a faculty member after a postdoctoral fellowship at MIT. He is a world-renowned scientist in photonics, electron microscopy, light–matter interactions, quantum information processing, and mathematical discoveries using artificial intelligence. His scientific work has earned him numerous honors, including the Stanisław Lem Prize, the Schmidt Science Polymath Award, the Blavatnik Award, the Krill Prize, and election to the Israeli Young Academy.

His new grant will be used to develop Stork – an innovative module that improves the performance of transmission electron microscopes (TEM). These instruments are widely adopted for biological applications as well as semiconductor metrology and inspection. However, their capabilities across both fields are highly limited owing to low contrast, which hinders resolution and throughput. The Stork technology makes it possible to introduce light directly onto the studied specimen, while also efficiently collecting the light emitted from it, thereby enhancing the TEM imaging capabilities dramatically. This paradigm shift in TEM technology will provide unprecedented information for imaging biological tissues and atomic-scale defects in electronic devices. The research team behind the winning proposal includes Dr. Tal FishmanDr. Michael Yannai, and Dr. Raphael Dahan, as well as students Marta Rozhenko and Rotem Elimelech.

JERUSALEM, Jan 27 (Reuters) – Boeing (BA.N), opens new tab and Israel’s Technion university said on Tuesday they were beginning to develop Sustainable Aviation Fuel (SAF) from feedstocks including green hydrogen and carbon dioxide to enable the aviation sector’s long-term growth.

SAF, made largely from waste or used cooking oil, can cut emissions significantly compared with traditional jet fuel. However, it remains two to five times more expensive than conventional fuel.

Boeing and Technion said following the completion of an initial feasibility phase, development was set to begin and move towards “competitive commercial production.”

Boeing has committed to delivering commercial airplanes capable of flying 100% on SAF by 2030, while the commercial aviation industry seeks to achieve zero net emissions by 2050.

Although airline industry leaders have pointed to a wave of new SAF initiatives they say will spark a boom similar to the rapid rise of electric vehicles and solar energy, the International Air Transport Association (IATA), a global body that represents 340 airlines, forecast SAF would account for only 0.7% of total jet fuel in 2025, and the 2050 target could be missed.

Boeing said the process to develop SAF on a large scale could still take a few years. SAF can be made from a variety of sources such as cover crops and other non-edible plants, agricultural and forestry waste, non-recyclable municipal waste, industrial plant off-gassing and other feedstocks

Separately, Boeing and Israel’s Ben-Gurion University said they were establishing a cybersecurity research centre for next-generation aviation and aerospace systems.

Boeing Global President Brendan Nelson, currently in Israel, said the company was working to “enhance energy security, support the growth of the civil aviation industry, and create new economic opportunities through sustainable aviation fuel and other technologies.”

Technion President Uri Sivan said it was on a mission to develop technologies for producing clean fuels that would make a “significant contribution to aviation—and no less importantly, to human health and the environment.”

Researchers at the Technion Faculty of Biology have discovered that a mechanism responsible for breaking down toxic proteins, and known to be involved in the development of Alzheimer’s disease, may actually spread these proteins to neighboring cells, thereby promoting the progression of the disease in the brain

A research group led by Professor Michael Glickman, dean of the Technion’s Faculty of Biology, has uncovered a key mechanism in the development of Alzheimer’s. The mechanism in question identifies toxic proteins and disposes of them. In most cases, harmful proteins are degraded inside the cell. However, the researchers found that in certain situations, the very system meant to eliminate these proteins simply transfers them outside the cell. This discovery may explain how a disease that begins randomly in individual neurons can spread to large regions of the brain.

The study, published in PNAS, was led by Prof. Glickman and postdoctoral researcher Dr. Ajay Wagh. In their article, they describe how brain cells deal with UBB+1, a defective and toxic variant of the protein ubiquitin.

The ubiquitin system is essential for breaking down damaged and dangerous proteins. Ubiquitin helps the body eliminate such proteins. The problem arises when ubiquitin mutates into UBB+1. Instead of protecting the cell, UBB+1 harms it, forming protein aggregates associated with the development of Alzheimer’s disease. In brain cells, this damage is particularly severe because neurons do not divide or regenerate – once a neuron dies, it cannot be replaced. One of the “gatekeepers” that prevents UBB+1 from poisoning brain cells is the protein p62, which is involved in the cellular self-cleaning process known as autophagy. Acting as a smart receptor, p62 recognizes UBB+1 and encloses it in a vesicle that prevents it from causing harm.

Next, one of two things happens: p62 either directs the vesicle to the lysosome, which is the cell’s recycling centre, or secretes it out of the cell into the intercellular brain fluid. The Technion researchers show that the second option may endanger brain tissue. Once the vesicle is expelled into the brain’s extracellular fluid, fragments of the toxic UBB+1 protein may leak into neighboring neurons, thereby accelerating the spread of Alzheimer’s pathology.

According to Prof. Glickman, “We all want someone to take out the trash, but in this case, the cells are dumping their trash on their neighbors. Although this solves an acute problem for the individual cell, it may cause long-term damage to the entire tissue. We believe that uncovering this mechanism will enable, first, early diagnosis of Alzheimer’s disease based on analyses of cerebrospinal and other body fluids, and second, the development of precise, personalized treatments.”

The study was supported by the Israel Science Foundation (ISF) and the European Research Council (ERC).