In the time it takes to read this article, several people in the United States will likely experience a heart attack — according to the CDC, someone in the US suffers from one every 40 seconds.
That morbid statistic highlights the importance of coronary artery disease detection methods, and companies developing them.
One such company is Israeli startup AccuLine, which recently secured $4.2 million in seed funding for the development and commercialisation of its CORA (Coronary Artery Risk Assessment) system, designed to improve the early detection of coronary artery disease (CAD), a leading cause of heart attacks.
CORA detects two bio-signals in the heart’s electrical activity, providing insights into coronary artery health. The system uses artificial intelligence and machine-learning algorithms to analyse this data, identifying patterns that may indicate CAD.
The CORA assessment improves upon current CAD diagnostic tools by means of a noninvasive, radiation-free test that evaluates three vital signs — the heart’s electrical activity, oxygen saturation levels and respiratory phase — in four minutes.
The system is designed to be operated by medical staff in various healthcare settings, with immediate results. By potentially replacing some existing stress test examinations, CORA could reduce medical expenses while maintaining diagnostic accuracy.
AccuLine, based in Petah Tikva, estimates the market potential for the technology at $7 billion annually in the United States.
The company has conducted two clinical studies in Israel to validate CORA’s diagnostic capabilities. The first involved 100 participants, while the second, larger study included 300 participants across seven medical centers. A third study is planned for next year in the US to seek US Food and Drug Administration (FDA) approval.
“Diagnosing patients at very early stages of risk for CAD without invasive testing will add value to patients, healthcare systems, doctors and insurance organisations,” said AccuLine cofounder and CEO Moshe Barel.
“This test has the potential to save millions of lives a year and save hundreds of millions of dollars for healthcare systems on unnecessary tests or expensive treatments for patients after a heart attack, including rehabilitation and medication.”