Shai Shen-Orr

Professor Shai Shen-Orr is a computational biologist who specializes in applying computer science and information technology to biology and medicine, particularly immunology. He heads the multidisciplinary Systems Immunology & Precision Medicine Laboratory at the Technion Faculty of Medicine and is a member of the Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering. Prof. Shen-Orr is also the co-founder and chief scientist of CytoReason, a company that uses an artificial intelligence model of the immune system to identify disease mechanisms and inform decision support in drug development.

Prof. Shen-Orr is developing analytical methodologies for unraveling the complexities of the immune system, which he has applied to understand the workings of the immune system in disease and aging. He is also identifying diagnostic biomarkers that evaluate immune health, and, in particular, a metric that gauges one’s “immune age,” a more accurate measure of health than chronological age. His work could advance the diagnosis and treatment of immune-related disease.

His research has been cited over 12,000 times and been featured in systems biology textbooks for students. He has coauthored 43 scholarly papers and is a frequent participant in international conferences.